A fast and sensitive liquid chromatographic–tandem mass spectrometric method for assay of lorazepam and application to pharmacokinetic analysis

Zhu, Honghui; Luo, Jinwen

doi:10.1016/j.jpba.2005.02.024

Cited by 20 publications

(11 citation statements)

References 40 publications

(48 reference statements)

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“…Plasma concentrations of lorazepam were measured by a method developed by Zhu and Luo (42). Analyses were performed on a coupled high performance liquid chromatographelectrospray tandem mass spectrometer (Waters Micromass Quatro Ultima).…”

Section: Methodsmentioning

confidence: 99%

The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory

Marino¹,

Pakhomov²,

Han³

et al. 2012

Epilepsy & Behavior

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This is the first study of the effect of topiramate on linguistic behavior and verbal recall using a computational linguistics system for automated language and speech analysis to detect and quantify drug-induced changes in speech recorded during discourse level tasks. Healthy volunteers were administered a single, 100 mg oral dose of topiramate in two double-blind, randomized, placebo-controlled, crossover studies. Subjects’ topiramate plasma levels ranged from 0.23–2.81ug/mL. We found a significant association between topiramate levels and impairment on measures of verbal fluency elicited during a picture description task, correct number of words recalled on a paragraph recall test, and reaction time recorded during a working memory task. Using the tools of clinical pharmacology and computational linguistics, we elucidated the relationship between the determinants of a drug’s disposition as reflected in plasma concentrations and their impact on cognitive functioning as reflected in spoken language discourse.

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Section: Methodsmentioning

confidence: 99%

The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory

Marino¹,

Pakhomov²,

Han³

et al. 2012

Epilepsy & Behavior

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show abstract

“…Plasma concentrations of LOR were measured by a method developed by Zhu and Luo [13]. Analyses were performed on a coupled high performance liquid chromatograph-electrospray tandem mass spectrometer (Waters Micromass Quatro Ultima).…”

Section: Blood Sampling and Drug Analysismentioning

confidence: 99%

Acute lorazepam effects on neurocognitive performance

Loring

Marino

Parfitt

et al. 2012

Epilepsy & Behavior

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“…Em processos heterogêneos como Feº, a adsorção do contaminante na superfície das partículas do Feº é uma preocupação relatada por vários autores (NORADOUN et al, 2003;ZHOU et al, 2009 [Feº] 25 g L -1 sem pré-trat.…”

Section: Feº E Edtaunclassified

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Bautitz¹

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A fast and sensitive liquid chromatographic–tandem mass spectrometric method for assay of lorazepam and application to pharmacokinetic analysis

Cited by 20 publications

References 40 publications

The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory

The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory

Acute lorazepam effects on neurocognitive performance

Degradação de fármacos por processo foto-Fenton e ferro metálico

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