A Faraday Rotation Spectrometer for study of NO isotopes in breath

Wang, Yin; Cikach, Frank; Barnes, Jarrod W.; Dababneh, Luma; Grove, David; Erzurum, Serpil; Comhair, Suzy; Kao, Christina C.; Dweik, Raed A.; Wysocki, Gerard

doi:10.1364/cleo_at.2013.af1l.5

Cited by 2 publications

(3 citation statements)

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“…133 Furthermore, it has been used in a clinical setup for off-line analysis of nitrite/ nitrate in urine after chemical conversion to NO. 134 Labelled and unlabelled NO metabolites were detected and quantified in urine samples collected before and after administration of 15 N-arginine (see Fig. 3B).…”

Section: Qcl-ir Spectroscopy For Breath Analysismentioning

confidence: 99%

Quantum cascade lasers (QCLs) in biomedical spectroscopy

2017

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Quantum cascade lasers (QCL) are the first room temperature semiconductor laser source for the mid-IR spectral region, triggering substantial development for the advancement of mid-IR spectroscopy. Mid-IR spectroscopy in general provides rapid, label-free and objective analysis, particularly important in the field of biomedical analysis. Due to their unique properties, QCLs offer new possibilities for development of analytical methods to enable quantification of clinically relevant concentration levels and to support medical diagnostics. Compared to FTIR spectroscopy, novel and elaborated measurement techniques can be implemented that allow miniaturized and portable instrumentation. This review illustrates the characteristics of QCLs with a particular focus on their benefits for biomedical analysis. Recent applications of QCL-based spectroscopy for analysis of a variety of clinically relevant samples including breath, urine, blood, interstitial fluid, and biopsy samples are summarized. Further potential for technical advancements is discussed in combination with future prospects for employment of QCL-based devices in routine and point-of-care diagnostics.

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Section: Qcl-ir Spectroscopy For Breath Analysismentioning

confidence: 99%

Quantum cascade lasers (QCLs) in biomedical spectroscopy

2017

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“…Because f L ≫ f M , the 1∕f laser intensity noise at f L is significantly lower than at f M , and the EMI pickup that occurs at f M is also eliminated by demodulation at f L . The effectiveness of DM-FRS compared to AC-FRS has already been demonstrated by near shot-noise limited measurements of NO in a medical breath analysis application [10][11][12]. In this Letter, we report the successful application of DM-FRS to the detection of HO 2 from an atmospheric flow reactor.…”

mentioning

confidence: 82%

“…To overcome the technical limitations of AC-FRS, a new detection method has been developed that relies on high-frequency wavelength modulation of the laser (f L ) with simultaneous modulation of the magnetic field (f M ) [10][11][12]. In this dual modulation (DM)-FRS method, the modulated magnetic field creates additional amplitude modulation (AM) of the wavelength-modulated FRS signal at frequency f L .…”

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confidence: 99%

Dual modulation Faraday rotation spectroscopy of HO_2 in a flow reactor

et al. 2014

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The technique of dual modulation Faraday rotation spectroscopy (DM-FRS) has been applied to achieve technical-noise-limited detection of HO2 at the exit of an atmospheric pressure flow reactor. This was implemented by combining direct current modulation at 51 kHz of an external cavity quantum cascade laser system with 610 Hz modulation of the magnetic field generated by a Helmholtz coil. The DM-FRS measurement had a 1.5 times better signal-to-noise ratio than a conventional FRS measurement acquired under identical flow reactor conditions. High harmonic detection of the FRS signal also eliminated the substantial offset associated with electromagnetic interference pickup from the Helmholtz coils that is observed in the conventional FRS spectrum. A noise equivalent angle of 8.9×10(-9) rad Hz(-1/2) was measured for the DM-FRS measurement, corresponding to a 3σ detection limit for HO2 of 0.35 ppmv Hz(-1/2).

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A Faraday Rotation Spectrometer for study of NO isotopes in breath

Cited by 2 publications

References 3 publications

Quantum cascade lasers (QCLs) in biomedical spectroscopy

Quantum cascade lasers (QCLs) in biomedical spectroscopy

Dual modulation Faraday rotation spectroscopy of HO_2 in a flow reactor

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