A Family With Histologically Confirmed Alzheimer's Disease

Nee, Linda E.; Polinsky, Ronald J.; Eldridge, Roswell; Weingartner, Herbert; Smallberg, Sheila A.; Ebert, Michael H.

doi:10.1001/archneur.1983.04050040033004

Cited by 164 publications

(43 citation statements)

References 20 publications

(2 reference statements)

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“…A relation between symptom progression in Alzhei mer's disease and age of onset was reported by some investigators [2,4,16], Albert [2] found that Alzheimer cases with an early onset compared to late-onset cases 22 Haupt/Kurz/Pollmann Symptom Severity and Progression in Alzheimer's Disease Numbers in brackets = maximum score. 1 None of the values were statistically significant (a = 0.05).…”

Section: Discussionmentioning

confidence: 75%

Severity of Symptoms and Rate of Progression in Alzheimer's Disease: A Comparison of Cases with Early and Late Onset

Haupt¹,

Kurz²,

Pollmann³

1992

Dement Geriatr Cogn Disord

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Since first description of Alzheimer''s disease rapid symptom progression and relatively severe cognitive symptoms have been frequently associated with early age of onset, while slow symptom progression and relatively mild cognitive symptoms were often related to late age of onset. In a longitudinal study of 90 patients with mild to moderate Alzheimer''s disease, we investigated these hypotheses. We found that neither severity of cognitive symptoms nor symptom progression in Alzheimer''s disease were associated with age of onset. In addition, a comparison of extreme groups (group 1: < 60 years of age; group 2: > 75 years of age), taken from the study sample, showed similar results with respect to the independent variables. These results suggest that the interindividual variability of cognitive impairment as well as the large variation of symptom progression in Alzheimer''s disease cannot be explained by age of onset.

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Section: Discussionmentioning

confidence: 75%

Severity of Symptoms and Rate of Progression in Alzheimer's Disease: A Comparison of Cases with Early and Late Onset

Haupt¹,

Kurz²,

Pollmann³

1992

Dement Geriatr Cogn Disord

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“…Through genealogical investigations in the 1940s and 1950s, it was demonstrated that AD sometimes appears as an autosomal dominant mendelian trait [5]. That is, multiple generations are affected, males and females are equally affected and the children of affected persons are at a nearly 50% risk for developing dementia [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Life Situation, Coping and Quality of Life in People with High and Low Risk of Developing Alzheimer’s Disease

Axelman

Lannfelt²,

Almkvist³

et al. 2003

Dement Geriatr Cogn Disord

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The psychosocial consequences of being at different risk for inheriting Alzheimer’s disease (AD) were investigated in a high-risk group (n = 106) and a low-risk group (n = 37). Non-affected individuals from families with AD in two or more generations answered questions about their life situation, quality of life and coping. Their answers were compared with a population sample (n = 408). The high-risk group assessed the quality of their personal relationships and everyday life higher than did the population sample. They also used less emotive and supportive coping strategies compared with the population sample. Nearly 90% in the high-risk group felt anxiety concerning their own risk or the risk of their children and grandchildren of developing AD. About 50% of the respondents complained about a lack of information. The pieces of information they asked for were early signs of the disease, treatment, and practical information on how to handle everyday life with an affected relative.

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“…In more modern times a family was reported with 51 affected persons in 8 generations (Nee et al, 1983). Down syndrome individuals who are trisomic for chromosome 21 (C21) and have 3 copies of the APP gene also develop A pathology (Heston, 1977).…”

Section: Monogenic Formsmentioning

confidence: 99%