A family study of hidradenitis suppurativa.

Fitzsimmons, J S; Guilbert, P

doi:10.1136/jmg.22.5.367

Cited by 105 publications

(66 citation statements)

References 8 publications

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“…35 Sex hormone binding globulin can be decreased in those with excess body weight, and this factor was not corrected for in previous studies. 14 Barth et al 35 compared females with HS to body mass indexematched controls. Both groups were also matched for hirsutism, which was previously thought to be related to higher androgen levels.…”

mentioning

confidence: 98%

“…Both males and females were affected via vertical transmission through several generations, consistent with AD inheritance. 7,14 Many of the first-degree relatives were under 20 years of age during the study. It was hypothesized that if the study subjects were followed for longer periods of time, more of them might develop the disease, bringing the percentage of those affected closer to 50%.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Hidradenitis suppurativa: A comprehensive review

Alikhan

Lynch²,

Eisen³

2009

Journal of the American Academy of Dermatology

595

636

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mentioning

confidence: 98%

mentioning

confidence: 99%

Hidradenitis suppurativa: A comprehensive review

Alikhan

Lynch²,

Eisen³

2009

Journal of the American Academy of Dermatology

595

636

View full text Add to dashboard Cite

“…Up to 40% of HS patients know a family member with similar symptoms [14]. In a minority of families, HS is inherited in an autosomal dominant pattern [15] but HS does not seem to be associated with HLA genotypes [16]. The first HS-associated loci in a family with autosomal dominant inheritance were at 6q25.2 and chromosome 19 [17].…”

Section: Gamma-secretase Knockout Micementioning

confidence: 99%

Can Animal Skin Diseases or Current Transgenic Mice Serve as a Model for Hidradenitis Suppurativa?

Zee

Laman²,

Prens³

2012

Dermatology

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The pathogenesis of hidradenitis suppurativa (HS) is still enigmatic, and a valid animal model for HS is currently not available. The recent discovery of γ-secretase mutations in a subpopulation of patients with HS suggested γ-secretase transgenic mice as a model for HS pathogenesis. However, the discrepancies between human HS and these mice are daunting. We critically review cases of animal HS and transgenic γ-secretase mouse models for HS and discuss the criteria which should be met for a representative pathogenic model.

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“…A genetic predisposition for the disease may exist. Fitzsimmons and Guilbert [18 ]reported that 34% of the first-degree relatives of HS patients also suffered from the disease. HS may segregate as an autosomal dominant trait [19].…”

Section: Introductionmentioning

confidence: 99%

Aerobic and Anaerobic Bacteriology of Hidradenitis Suppurativa: A Study of 22 Cases

Katoulis

Koumaki

Liakou

et al. 2015

Skin Appendage Disord

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Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unclear etiology. The role of bacteria in the pathogenesis of disease remains controversial. Materials and Methods: Specimens were obtained from 22 HS patients by direct percutaneous needle aspiration. The collected material was cultured in aerobic and anaerobic conditions, and sensitivity tests were performed. Results: Of the 22 patients, 32% were culture negative and 68% were culture positive. A total of 16 isolates was obtained, 14 aerobic and 2 anaerobic. Aerobic bacteria were present in 86% of the specimens, whereas only anaerobic bacteria were isolated in 7%. The predominant aerobic species were Proteus mirabilis, Staphylococcus haemolyticus and Staphylococcus lugdunensis. The isolated anaerobic bacteria were Dermacoccus nishinomiyaensis and Propionibacteriumgranulosum. Conclusion: A variety of aerobic and anaerobic bacteria was isolated from the HS lesions of our patients. In contrast to previous studies, fewer patients were found to be culture positive, and Staphylococcus aureus was isolated in only 1 of them. More studies are necessary to elucidate the controversial role of bacteria in the pathogenesis of HS.

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A family study of hidradenitis suppurativa.

Cited by 105 publications

References 8 publications

Hidradenitis suppurativa: A comprehensive review

Hidradenitis suppurativa: A comprehensive review

Can Animal Skin Diseases or Current Transgenic Mice Serve as a Model for Hidradenitis Suppurativa?

Aerobic and Anaerobic Bacteriology of Hidradenitis Suppurativa: A Study of 22 Cases

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