A family study of anticardiolipin antibodies and associated clinical conditions

Goldberg, S. Nahum; Conti-Kelly, Ann Marie; Greco, Thomas

doi:10.1016/s0002-9343(99)80222-8

Cited by 58 publications

(32 citation statements)

References 24 publications

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“…54,55 Some apparently acquired coagulopathies, such as the presence of a lupus anticoagulant or anticardiolipin antibody, can be familial in approximately 10% of cases. 56,57 Inherited disorders of various clotting factors (ie, factors V, VII, X, XI, and XIII) are autosomal recessive traits and can lead to cerebral hemorrhage in childhood or the neonatal period. 50 Arterial dissections, moyamoya disease, and fibromuscular dysplasia have a familial component in 10% to 20% of cases.…”

Section: Diagnostic Recommendationsmentioning

confidence: 99%

Guidelines for the Primary Prevention of Stroke

Goldstein¹,

Bushnell²,

Adams³

et al. 2011

Stroke

1,287

577

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Background and Purpose-This guideline provides an overview of the evidence on established and emerging risk factors for stroke to provide evidence-based recommendations for the reduction of risk of a first stroke. Methods-Writing group members were nominated by the committee chair on the basis of their previous work in relevant topic areas and were approved by the American Heart Association (AHA) Stroke Council Scientific Statement Oversight Committee and the AHA Manuscript Oversight Committee. The writing group used systematic literature reviews (covering the time since the last review was published in 2006 up to April 2009), reference to previously published guidelines, personal files, and expert opinion to summarize existing evidence, indicate gaps in current knowledge, and when appropriate, formulate recommendations using standard AHA criteria (Tables 1 and 2). All members of the writing group had the opportunity to comment on the recommendations and approved the final version of this document. The guideline underwent extensive peer review by the Stroke Council leadership and the AHA scientific statements oversight committees before consideration and approval by the AHA Science Advisory and Coordinating Committee. Results-Schemes for assessing a person's risk of a first stroke were evaluated. Risk factors or risk markers for a first stroke were classified according to potential for modification (nonmodifiable, modifiable, or potentially modifiable) and strength of evidence (well documented or less well documented). Nonmodifiable risk factors include age, sex, low birth weight, race/ethnicity, and genetic predisposition. Well-documented and modifiable risk factors include hypertension, exposure to cigarette smoke, diabetes, atrial fibrillation and certain other cardiac conditions, dyslipidemia, carotid artery stenosis, sickle cell disease, postmenopausal hormone therapy, poor diet, physical inactivity, and obesity and body fat

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Section: Diagnostic Recommendationsmentioning

confidence: 99%

Guidelines for the Primary Prevention of Stroke

Goldstein¹,

Bushnell²,

Adams³

et al. 2011

Stroke

1,287

577

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“…Many other studies have implicated genetic factors. In a series of 23 patients with aCL, 29 of their 87 relatives (33%) also had aCL [95]. In Canadian, German, Italian, and Mexican patients an association of aPL with HLA-DR7 has been observed, and in American and Spanish patients, with HLA-DQ [96].…”

Section: Fig (1) ß2-gp-i Interactions With Phospholipids and Antibomentioning

confidence: 96%

The Pathophysiology of Antiphospholipid Syndrome

Sada¹,

Cohen²,

Isenberg³

2015

TOUNJ

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“…Familial occurrence of lupus anticoagulant (LA) was first described in three sets of siblings, two of which had more than one clinically affected member (Exner et al, 1980). Subsequent studies have reported that first-degree relatives of patients with SLE or primary APS have a higher incidence of aCL antibodies, suggesting a genetic predisposition to the development of these antibodies (Mackworth-Young et al, 1987); (Goldberg et al, 1995). Identification of several pedigrees with an increased frequency of aPL antibodies and the associated clinical manifestations further support the familial form of APS.…”

Section: Family-based Studiesmentioning

confidence: 99%