A family of proteins implicated in axon guidance and outgrowth

Quinn, Christopher C.; Gray, Grace; Hockfield, Susan

doi:10.1002/(sici)1097-4695(199910)41:1<158::aid-neu19>3.0.co;2-0

Cited by 191 publications

(62 citation statements)

References 36 publications

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“…The LCRMP-1 can promote cancer cell invasion and functionally antagonize CRMP-1. The counter-regulatory effect of these two isoforms is consistent with what has been found in the non-human large isoforms of the CRMP family proteins, including TUC-4b in Quinn's study [8,16], and CRMP-2A in Yuasa-Kawada's study [17]. Quinn et al has demonstrated the presence of 75 kDa CRMP isoform, b form, in rats.…”

Section: Discussionsupporting

confidence: 80%

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Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non-small cell lung cancer patients

et al. 2010

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Section: Discussionsupporting

confidence: 80%

“…They are responsible for semaphorin 3A-mediated growth cone collapse of neuronal cells [7][8][9][10]. These phosphoproteins have 50-70% sequence homology with one another, being approximately 60-66 kDa in size, and can form heterotetramers [8,[11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non-small cell lung cancer patients

et al. 2010

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“…During brain development, TUC-4 is not expressed by progenitor cells but is expressed by postmitotic neurons as they begin their migration (Minturn et al 1995b). TUC-4 expression reaches its highest levels in all neurons during the peak of axonal growth and is down-regulated afterward but can be re-expressed during adulthood, e.g., by axotomy (Quinn et al 1999).…”

Section: Toad/ulip/crmpmentioning

confidence: 99%

Immunohistological markers for proliferative events, gliogenesis, and neurogenesis within the adult hippocampus

2011

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Biologists long believed that, once development is completed, no new neurons are produced in the forebrain. However, as is now firmly established, new neurons can be produced at least in two specific forebrain areas: the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampal formation. Neurogenesis within the adult DG occurs constitutively throughout postnatal life, and the rate of neurogenesis within the DG can be altered under various physiological and pathophysiological conditions. The process of adult neurogenesis within the DG is a multi-step process (proliferation, differentiation, migration, targeting, and synaptic integration) that ends with the formation of a post-mitotic functionally integrated new neuron. Various markers are expressed during specific stages of adult neurogenesis. The availability of such markers allows the time-course and fate of newly born cells to be followed within the DG in a detailed and precise fashion. Several of the available markers (e.g., PCNA, Ki-67, PH3, MCM2) are markers for proliferative events, whereas others are more specific for early phases of neurogenesis and gliogenesis within the adult DG (e.g., nestin, GFAP, Sox2, Pax6). In addition, markers are available allowing events to be distinguished that are related to later steps of gliogenesis (e.g., vimentin, BLBP, S100beta) or neurogenesis (e.g., NeuroD, PSA-NCAM, DCX).

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“…During brain development, the protein is not expressed by progenitor cells but is expressed by postmitotic neurons as they begin their migration (Minturn et al 1995b). TUC-4 expression reaches its highest expression levels in all neurons during the peak of axonal growth, is down-regulated afterwards, but can be reexpressed in adults, e.g., by axotomy (Quinn et al 1999). …”

Section: Tuc-4 Labelingmentioning

confidence: 99%

Immunohistological markers for staging neurogenesis in adult hippocampus

2007

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Neurogenesis in the adult dentate gyrus (DG) of the hippocampus occurs constitutively throughout postnatal life, and the rate of neurogenesis within the DG can be altered under various physiological and pathophysiological conditions. Adult neurogenesis includes the process in which the division of a precursor cell takes place and the multi-step process (proliferation, differentiation, migration, targeting, and synaptic integration) that ends with the formation of a postmitotic functionally integrated new neuron. During specific time-frames of adult neurogenesis, various markers are expressed that correlate with the differentiation steps along the pathway from early progenitor cells to newly generated postmitotic neurons within the DG. Markers that are currently widely used for the investigation of adult hippocampal neurogenesis are: glial fibrillary acidic protein, nestin, Pax6, NeuroD, PSA-NCAM, doublecortin, TUC-4, Tuj-1, and calretinin. The discovery and development of specific markers that allow the time-course and fate of neurons to be followed during adult neurogenesis in a detailed and precise fashion are not only helpful for gaining further insights into the genesis of new neurons in the hippocampus, but also might be applicable to the development of strategies for therapeutic interventions.

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A family of proteins implicated in axon guidance and outgrowth

Cited by 191 publications

References 36 publications

Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non-small cell lung cancer patients

Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non-small cell lung cancer patients

Immunohistological markers for proliferative events, gliogenesis, and neurogenesis within the adult hippocampus

Immunohistological markers for staging neurogenesis in adult hippocampus

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