A Family of “Bombay” Blood Type with Suppression of Blood Group Substance A<sub>1</sub>

Aust, Charles H.; Keller, ZoEtta G.; Arbogast, J. L.

doi:10.1093/ajcp/37.6.579

Cited by 10 publications

(4 citation statements)

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“…Individuals with the so-called “Bombay” phenotype lack functional FUT1 and FUT2 enzymes and, therefore, lack both type 1 and type 2 H antigen ( Aust et al., 1962 ; Bhende et al., 1952 ; Dean, 2005 ; Levine et al., 1955 ; Reid and Olsson, 2012 ). As the H antigen is required for synthesizing A and B antigens, individuals with Bombay phenotype also do not generate A or B structures.…”

Section: Abo Blood Group Systemmentioning

confidence: 99%

ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies

Jajosky

Zheng

et al. 2023

iScience

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Section: Abo Blood Group Systemmentioning

confidence: 99%

ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies

Jajosky

Zheng

et al. 2023

iScience

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“…[1112] Later on, it was found that many of the European cases, which were initially labeled as typical Bombay phenotypes, turned out to be para-Bombay phenotypes after absorption-elution studies. [13–15] The difficulty with the Bombay phenotype is that the individuals having blood group of Bombay phenotype (Oh) can either receive autologous donation or blood from an individual of Bombay phenotype only; no other blood will match in case of an emergency blood transfusion.…”

Section: Introductionmentioning

confidence: 99%

Identification of a rare blood group, "Bombay (Oh) phenotype," in Bhuyan tribe of Northwestern Orissa, India

Balgir

2007

Indian J Hum Genet

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BACKGROUND:Blood group serology plays a vital role in transfusion medicine. The Bombay (Oh) phenotype is characterized by the absence of A, B, and H antigens on red cells and occurs rarely, especially in tribal populations of India.AIMS AND OBJECTIVES:This is a field-based random population study in the Bhuyan tribal community. The study reports three cases of the rare Bombay (Oh) phenotype for the first time in the Bhuyan tribe of Sundargarh district in North-Western Orissa.MATERIALS AND METHODS:Taking informed consent, red blood cells of 836 Bhuyan subjects were tested with three antisera, i.e., anti-A, anti-B, and anti-H (lectin) for forward reaction. Agglutinations of plasma with A, B, and O (H) red cells (reverse reaction) were also tested for the presence or absence of antibodies in the serum. Specialized tests like absorption-elution, titration of naturally occurring antibodies at different temperatures, inhibition of anti-H by O saliva secretor, and determination of secretor status were performed.RESULTS:Three cases of a rare blood group, Bombay (Oh) phenotype, (2 out of 244 Khandayat Bhuyan and 1 out of 379 Paudi Bhuyan from Hemgiri and Lahunipara blocks, respectively) in the Bhuyan tribe of Sundargarh district in North-Western Orissa were detected, giving an incidence of 1 in 122 in Khandayat Bhuyan and 1 in 379 in Paudi Bhuyan, with an average of 1 in 278 among the Bhuyan tribal population. This incidence is high in comparison to earlier studies reported from India.CONCLUSIONS:The practice of tribal and territorial endogamy in a smaller effective populations (for example, there are only 3,521 individuals in Paudi Bhuyan) results in smaller marital distance and inbreeding, leading to increased homozygous expression of rare recessive genetic characters like the Bombay (Oh) phenotype. This study further testifies that the incidence is higher in those states of India where the consanguinity is a common practice.

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“…Aust CH et al reported this occurrence in their paper published in 1962 in four individuals of same family. 8 A recent study in 2015 titled "Bombay Blood Group in a Turkish Family: Serological and Molecular Analysis" also describes similar clustering of Bombay blood group in a family. 9 Further in our case report it was also found that inheritance pattern was unusual for a autosomal recessive trait to express itself in first degree cousins.…”

Section: Discussionmentioning

confidence: 94%

Rare Incidental Detection Of Bombay Blood Group In A Patient Of Marfans Syndrome With Subsequent Clustering And Unusual Inheritance Pattern In Four Individuals Of Same Family In South West Region Of Punjab

Gupta

Chhabra

Singh

et al. 2020

APALM

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The Bombay Blood Group (Oh) is characterized by absence of normal ABH antigens and presence of corresponding antibodies in serum. This blood group is suspected when a sample doesn't show any reaction to anti-A and anti-B antibodies just like a normal O group would do but shows agglutination in reverse grouping or during antibody screening. Present case report highlights a case of 25 year old female who was incidentally detected having Bombay blood group and on further evaluation one sibling and two first degree cousins were also detected having Bombay blood group. Such a clustering of Bombay blood group cases in a single family is very rare and has never been reported in Punjab as per literature.

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A Family of “Bombay” Blood Type with Suppression of Blood Group Substance A₁

Cited by 10 publications

References 0 publications

ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies

ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies

Identification of a rare blood group, "Bombay (Oh) phenotype," in Bhuyan tribe of Northwestern Orissa, India

Rare Incidental Detection Of Bombay Blood Group In A Patient Of Marfans Syndrome With Subsequent Clustering And Unusual Inheritance Pattern In Four Individuals Of Same Family In South West Region Of Punjab

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A Family of “Bombay” Blood Type with Suppression of Blood Group Substance A1

Cited by 10 publications

References 0 publications

ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies

ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies

Identification of a rare blood group, "Bombay (Oh) phenotype," in Bhuyan tribe of Northwestern Orissa, India

Rare Incidental Detection Of Bombay Blood Group In A Patient Of Marfans Syndrome With Subsequent Clustering And Unusual Inheritance Pattern In Four Individuals Of Same Family In South West Region Of Punjab

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A Family of “Bombay” Blood Type with Suppression of Blood Group Substance A₁