A family history of knee joint replacement increases the progression of knee radiographic osteoarthritis and medial tibial cartilage volume loss over 10 years

Khan, Hussain; Aitken, Dawn; Chou, Louisa; McBride, Andrew; Ding, Changhai; Blizzard, Leigh; Pelletier, Jean‐Pierre; Pelletier, Johanne Martel; Cicuttini, Flavia Maria; Jones, Graeme

doi:10.1016/j.joca.2014.11.016

Cited by 21 publications

(15 citation statements)

References 32 publications

(26 reference statements)

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“…We and other groups have previously shown that injury‐induced OA is significantly affected by obesity . In addition, previous studies in humans have also indicated a strong correlation of obesity with the familial predisposition to OA . In the present study we also show that there are significant changes in the predisposition to injury‐induced OA, particularly in female F1 and F2 HFD mice, despite the fact that there were changes in body weight or composition in both male and female offspring.…”

Section: Discussionsupporting

confidence: 76%

Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice

Harasymowicz

Choi

et al. 2020

Arthritis & Rheumatology

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Objective Obesity and osteoarthritis (OA) are 2 major public health issues affecting millions of people worldwide. Whereas parental obesity affects the predisposition to diseases such as cancer or diabetes in children, transgenerational influences on musculoskeletal conditions such as OA are poorly understood. This study was undertaken to assess the intergenerational effects of a parental/grandparental high‐fat diet on the metabolic and skeletal phenotype, systemic inflammation, and predisposition to OA in 2 generations of offspring in mice. Methods Metabolic phenotype and predisposition to OA were investigated in the first and second (F1 and F2) generations of offspring (n = 10–16 mice per sex per diet) bred from mice fed a high‐fat diet (HFD) or a low‐fat control diet. OA was induced by destabilizing the medial meniscus. OA, synovitis, and adipose tissue inflammation were determined histologically, while bone changes were measured using micro–computed tomography. Serum and synovial cytokines were measured by multiplex assay. Results Parental high‐fat feeding showed an intergenerational effect, with inheritance of increased weight gain (up to 19% in the F1 generation and 9% in F2), metabolic imbalance, and injury‐induced OA in at least 2 generations of mice, despite the fact that the offspring were fed the low‐fat diet. Strikingly, both F1 and F2 female mice showed an increased predisposition to injury‐induced OA (48% higher predisposition in F1 and 19% in F2 female mice fed the HFD) and developed bone microarchitectural changes that were attributable to parental and grandparental high‐fat feeding. Conclusion The results of this study reveal a detrimental effect of parental HFD and obesity on the musculoskeletal integrity of 2 generations of offspring, indicating the importance of further investigation of these effects. An improved understanding of the mechanisms involved in the transmissibility of diet‐induced changes through multiple generations may help in the development of future therapies that would target the effects of obesity on OA and related conditions.

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Section: Discussionsupporting

confidence: 76%

Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice

Harasymowicz

Choi

et al. 2020

Arthritis & Rheumatology

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“…Smokers are also at risk for reduced bone density 42 and a 2013 study of radiographcially confirmed knee OA patients (K-L grade ≥2) found that longitudinal bone mineral density loss was associated with progressive knee cartilage loss 43 . Susceptibility to knee OA may be genetic 44 and in one study an association was found between smoking and knee cartilage loss among those with a family history of knee OA while controls (smoking with no family history of knee OA) had no such association 8 .…”

Section: Discussionmentioning

confidence: 99%

The relationship between smoking and knee osteoarthritis in the Osteoarthritis Initiative

Dubé

Liu

Driban

et al. 2016

Osteoarthritis and Cartilage

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Objective To estimate the extent that smoking history is associated with symptoms and disease progression among individuals with radiographically confirmed knee OA. Method Both cross-sectional (baseline) and longitudinal studies employed data from the Osteoarthritis Initiative (n= 2,250 participants). Smoking history was assessed at baseline with 44% current or former smokers. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was used to measure knee pain, stiffness, and physical function. Disease progression was measured using joint space width (JSW). We used adjusted multivariable linear models to examine the relationship between smoking status and exposure in pack years (PY) with symptoms and JSW at baseline. Changes in symptoms and JSW over time were further assessed. Results In cross-sectional analyses, compared to never-smokers high PY (≥15 PY) was associated with slightly greater pain (beta 0.36, 95% CI: 0.01–0.71) and stiffness (beta 0.20, 95% CI: 0.03–0.37); and low PY (<15 PY) was associated with better JSW (beta 0.15, 95% CI: 0.02–0.28). Current smoking was associated with greater pain (beta 0.59, 95% CI: 0.04–1.15) compared to never-smokers. These associations were not confirmed in the longitudinal study. Longitudinally, no associations were found between high or low PY or baseline smoking status with changes in symptoms (at 72 months) or JSW (at 48 months). Conclusion Cross-sectional findings are likely due residual confounding. The more robust longitudinal analysis found no associations between smoking status and symptoms or JSW. Long-term smoking provides no benefits to knee OA patients while exposing them to other well-documented serious health risks.

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“…Adding to prior data showing a considerable genetic and family history component to osteoarthritis, two new studies showed that having a parent with total knee replacement was associated with greater knee pain prevalence and worsening [33], as well as greater medial joint space narrowing over time [34]. …”

Section: Person-level Risk Factorsmentioning

confidence: 99%

State of the evidence

Allen

Golightly

2015

Current Opinion in Rheumatology

314

178

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Purpose of review This review focuses on recent studies of osteoarthritis epidemiology, including research on prevalence, incidence, and a broad array of potential risk factors at the person level and joint level. Recent findings Studies continue to illustrate the high impact of osteoarthritis worldwide, with increasing incidence. Person-level risk factors with strong evidence regarding osteoarthritis incidence and/or progression include age, sex, socioeconomic status, family history, and obesity. Joint-level risk factors with strong evidence for incident osteoarthritis risk include injury and occupational joint loading; the associations of injury and joint alignment with osteoarthritis progression are compelling. Moderate levels of physical activity have not been linked to increased osteoarthritis risk. Some topics of high recent interest or emerging evidence for association with osteoarthritis include metabolic pathways, vitamins, joint shape, bone density, limb length inequality, muscle strength and mass, and early structural damage. Summary Osteoarthritis is a complex, multifactorial disease, and there is still much to learn regarding mechanisms underlying incidence and progression. However, there are several known modifiable and preventable risk factors, including obesity and joint injury; efforts to mitigate these risks can help to lessen the impact of osteoarthritis.

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A family history of knee joint replacement increases the progression of knee radiographic osteoarthritis and medial tibial cartilage volume loss over 10 years

Cited by 21 publications

References 32 publications

Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice

Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice

The relationship between smoking and knee osteoarthritis in the Osteoarthritis Initiative

State of the evidence

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