A family history of cancer and lung cancer risk in never-smokers: A clinic-based case–control study

Lin, Huan; Huang, Yi; Yan, Hong‐Hong; Yang, Xue‐Ning; Zhong, Wen‐Zhao; Ye, Huan-Wen; Yang, Jing; Zhou, Qing; Wu, Yi‐Long

doi:10.1016/j.lungcan.2015.05.017

Cited by 42 publications

(46 citation statements)

References 16 publications

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“…Environmental tobacco smoke during early life is an important risk factor for lung cancer. Clustering of smoking habits in families has also been suggested, and some previous studies have considered this issue (Jonsson et al 2004;Lorenzo Bermejo and Hemminki 2005;Gao et al 2009;Lin et al 2015). To precisely identify the genetic component of family history, it may be necessary to control for any family history of smoking.…”

Section: Discussionmentioning

confidence: 99%

Association between Family History of Cancer and Lung Cancer Risk among Japanese Men and Women

Yoshida

Takizawa

Nishino

et al. 2019

Tohoku J. Exp. Med.

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Although cigarette smoking is a major risk factor for lung cancer, genetic susceptibility may also affect lung cancer risk. To explore the role of genetic risk, this case-control study investigated the association between family history of cancer at several sites and lung cancer risk. A total of 1,733 lung cancer cases and 6,643 controls were selected from patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2009. Information on family history of cancer was collected using a self-administered questionnaire and odds ratios (ORs) were estimated by unconditional logistic regression. Family history of lung cancer in first-degree relatives was associated with an increased risk of lung cancer among both sexes. According to histology and type of relatives, a parental history of lung cancer was significantly associated with an increased risk of female adenocarcinoma (OR = 1.72). Stratification by smoking status revealed that this significant positive association in women was limited to ever-smokers (OR = 4.13). In men, a history of lung cancer in siblings was significantly associated with an increased risk of small cell carcinoma (OR = 2.28) and adenocarcinoma (OR = 2.25). Otherwise, positive associations between history of breast (OR = 1.99) and total (OR = 1.71) cancers in siblings and the risk of male adenocarcinoma were observed. These results suggest that inherited genetic susceptibility may contribute to the development of lung cancer. In men, shared exposure to environmental factors among siblings may also be responsible for the increase in lung cancer risk.

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Section: Discussionmentioning

confidence: 99%

Association between Family History of Cancer and Lung Cancer Risk among Japanese Men and Women

Yoshida

Takizawa

Nishino

et al. 2019

Tohoku J. Exp. Med.

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“…[6,7] It can be seen that excluding environmental factors, the difference in risk of LC among individuals may be related to genetic factors, which is also considered to be an influential factor that lead to the incidence of LC. [8,9] Genome-wide association studies (GWAS) have been identified Ivyspring International Publisher several susceptibility gene locus of cancer, some of which increase the susceptibility of LC. [10][11][12] The identification of gene mutations that are important to the susceptibility of LC will contribute to a better understanding of the pathogenesis of LC and may lead to new approaches of disease treatment or prevention.…”

Section: Introductionmentioning

confidence: 99%

Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis

Li¹,

Liu²,

Liu³

et al. 2019

J. Cancer

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Purpose: The aim of this meta-analysis was to investigate polymorphism of Bsm1, Apal, Taq1 and Cdx-2 in vitamin D receptor (VDR) associations in relation to lung cancer (LC) susceptibility. Methods: 9 literatures were recruited into this meta-analysis from PubMed, PMC, Embase, Web of Science, Cochrane library and CNKI. STATA version 15.1 was used for statistical tests. The heterogeneity was tested using I 2 statistics. According to the value of I 2 , the random-effect model (REM) or fixed-effect model (FEM) was selected to combine data from studies, respectively. Potential publication bias was evaluated by Egger's test. Sensitivity analysis was also performed to evaluate the stability and reliability in results. Results: Decreased susceptibility of LC was found in all genetic models contrast in Bsm1 gene of VDR (a vs. A: OR = 0.62, 95 % CI = 0.44-0.87; aa vs. AA: OR = 0.76, 95 % CI = 0.60-0.96; Aa vs. AA: OR = 0.59, 95 % CI = 0.39-0.88; aa vs. AA+Aa: OR = 0.80, 95 % CI = 0.64-0.99; Aa+aa vs. AA: OR = 0.57, 95 % CI = 0.37-0.86). The similar results were also found in partial genetic models of Taq1 (a vs. A: OR = 0.88, 95 % CI = 0.79-0.98; aa vs. AA+Aa: OR = 0.84, 95 % CI = 0.73-0.98) and Cdx-2 (Aa vs. AA: OR = 0.80, 95 % CI = 0.66-0.98; Aa+aa vs. AA: OR = 0.79, 95 % CI = 0.65-0.96). Likewise, significant correlation between Bsm1, Taq1 polymorphism and LC risk was detected among Asians. Cdx-2 polymorphism was considered as a protective factor in Caucasians, whereas no association of Apal polymorphism with LC risk was observed in Asians and Caucasians for all genetic models. Conclusion: The results of this meta-analysis suggested that Bsm1, Taq1 and Cdx-2 polymorphism may contribute to lung cancer susceptibility, more studies need be conducted to confirm in the future.

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“…They did control for smoking, and the RRs for the different histologic subtypes were similar to the overall RR previously published for data on Utah. 5 Two studies examined the risk for the development of lung cancer in never-smokers 28,29 ; both showed increased risk for lung cancer in individuals with a family history of lung cancer. In both studies, a significant proportion of patients harbored an EGFR mutation, which hints at an inherited predisposition.…”

Section: Discussionmentioning

confidence: 99%

“…Lin et al found that female first-degree relatives of individuals with lung cancer tended to have higher risk for lung cancer than male first-degree relatives. 28 Typically studies of lung cancer risk in individuals with a family history that include consideration of sex have noted equivalent patterns in male and female probands. 32 This analysis may have some limitations.…”

Section: Discussionmentioning

confidence: 99%

Genetic Contribution to Nonsquamous, Non–Small Cell Lung Cancer in Nonsmokers

Carr

Akerley

Cannon-Albright

2018

Journal of Thoracic Oncology

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A family history of cancer and lung cancer risk in never-smokers: A clinic-based case–control study

Cited by 42 publications

References 16 publications

Association between Family History of Cancer and Lung Cancer Risk among Japanese Men and Women

Association between Family History of Cancer and Lung Cancer Risk among Japanese Men and Women

Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis

Genetic Contribution to Nonsquamous, Non–Small Cell Lung Cancer in Nonsmokers

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