A family-based study of hyperinsulinemia and hypertriglyceridemia in heterozygous lipoprotein lipase deficiency

Ikeda, Yasuyuki; Takagi, Atsuko; Nakata, Yuusei; Sera, Yasuyuki; Hyoudou, Sumio; Hamamoto, Kazuko; Nishi, Yoshikazu; Yamamoto, Akira

doi:10.1016/s0009-8981(01)00746-x

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“…Previous evidences showed that carriers with LPL heterozygous had a trend to hyperinsulinemia which indicated the presence of insulin resistance [8,9]. Our study suggests that with aging, systemic LPL deficiency causes increased lipid accumulation in tissues (liver, skeletal muscle, pancreas), which results in tissue-specific and whole-body insulin resistance, b-cell dysfunction and even impaired glucose tolerance ultimately.…”

Section: Discussionmentioning

confidence: 50%