A familial spontaneous epileptic feline strain: A novel model of idiopathic/genetic epilepsy

Kuwabara, Takayuki; Hasegawa, Daisuke; Ogawa, Fukie; Kobayashi, Masanori; Fujita, Michio; Suzuki, Hiroyoshi; Matsuki, Naoaki; Orima, Hiromitsu

doi:10.1016/j.eplepsyres.2010.08.010

Cited by 40 publications

(39 citation statements)

References 14 publications

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“…21 Although the mode of inheritance was not identified, the investigators proposed a genetic cause. Because of a lack of available genetic testing in cats, the term unknown epilepsy may be more appropriate than the term idiopathic.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004–2013)

Finnerty¹,

Heller²,

Mercier³

et al. 2014

javma

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Seizure control was achieved in most cats with a serum PB concentration between 15 and 45 μg/mL, regardless of the cause of the seizures. A modified 2011 ILAE classification was applied to cats with seizures and enabled classification of cats without specific genetic testing and without identified structural or inflammatory disease. This classification system should be incorporated into veterinary neurology nomenclature to standardize communication between veterinarians and improve comparisons among species.

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Section: Discussionmentioning

confidence: 99%

Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004–2013)

Finnerty¹,

Heller²,

Mercier³

et al. 2014

javma

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show abstract

“…A hereditary basis for epilepsy has been documented in several breeds of dogs, including Labrador Retrievers, German Shepherd Dogs, Golden Retrievers, Bernese Mountain Dogs, Belgian Tervurens, Vizslas, Keeshonds, English Springer Spaniels, and Border Collies . Although epileptic syndromes with a suspected genetic basis have recently been identified in cats, there is currently insufficient evidence to validate the use of the term genetic epilepsy in that species . Instead it has been suggested that the term unknown or presumptive unknown epilepsy be used in cats with epileptic seizures in which no underlying etiology can be identified .…”

Section: Etiology and Epidemiologymentioning

confidence: 99%

Status epilepticus in dogs and cats, part 1: etiopathogenesis, epidemiology, and diagnosis

Golubovic

Rossmeisl

2017

J Vet Emergen Crit Care

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“…The European shorthair breed was slightly overrepresented in cats with IE, but this finding cannot be considered as proof of a genetic origin for IE. Recently, a possible spontaneous model of human genetic epilepsy was detected in laboratory cats …”

Section: Diagnostic Evaluation Of a Cat With Suspected Epileptic Seizurementioning

confidence: 99%

Epilepsy in Cats: Theory and Practice

Pákozdy

Halász

Klang

2014

Veterinary Internal Medicne

102

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The veterinary literature on epilepsy in cats is less extensive than that for dogs. The present review summarizes the most important human definitions related to epilepsy and discusses the difficulties in applying them in daily veterinary practice. Epileptic seizures can have a wide range of clinical signs and are not necessarily typical in all cases. Whether a seizure event is epileptic can only be suspected based on clinical, laboratory, and neuroimaging findings as electroencephalography diagnostic techniques have not yet been developed to a sufficiently accurate level in veterinary medicine. In addition, the present review aims to describe other diagnoses and nonepileptic conditions that might be mistaken for epileptic seizures. Seizures associated with hippocampal lesions are described and discussed extensively, as they seem to be a special entity only recognized in the past few years. Furthermore, we focus on clinical work‐up and on treatment that can be recommended based on the literature and summarize the limited data available relating to the outcome. Critical commentary is provided as most studies are based on very weak evidence.

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A familial spontaneous epileptic feline strain: A novel model of idiopathic/genetic epilepsy

Cited by 40 publications

References 14 publications

Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004–2013)

Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004–2013)

Status epilepticus in dogs and cats, part 1: etiopathogenesis, epidemiology, and diagnosis

Epilepsy in Cats: Theory and Practice

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