A familial occurrence of allergic bronchopulmonary aspergillosis: A probable environmental source

Jm, Halwig; Vp, Kurup; Pa, Greenberger; Patterson, Roy

doi:10.1016/0091-6749(85)90804-8

Cited by 13 publications

(6 citation statements)

References 11 publications

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“…In unsensitised mice, chronic intranasal administration of mould spores or extracts can lead to allergic lung inflammation, hyper-reactivity and lung remodelling [ 7 ], but the effect in humans is unclear. Cases of ABPA within families suggest a common genetic basis with low penetrance [ 8 , 9 ]. In one case series from India, 5 % of cases were found to be familial in nature [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study

Overton

Denning

Bowyer

et al. 2016

Allergy Asthma Clin Immunol

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BackgroundIn patients with asthma, the fungus Aspergillus fumigatus can cause allergic bronchopulmonary aspergillosis (ABPA). Familial ABPA is reported, and some genetic factors have been associated with the disease, however, these are small studies (n ≤ 38) and do not explain all cases of ABPA.MethodsWe analysed SNPs in 95 ABPA patients, comparing frequencies to 152 atopic asthmatic and 279 healthy controls. Twenty two genes were selected from literature, and 195 tagging SNPs were analysed for genetic association with ABPA using logistic regression corrected for multiple testing. We also analysed monocyte-derived macrophage gene expression before and during co-culture with A. fumigatus.ResultsSeventeen ABPA-associated SNPs (ABPA v Atopic asthma) were identified. Three remained significant after correction for multiple testing; IL13 rs20541, IL4R rs3024656, TLR3 rs1879026. We also identified minor differences in macrophage gene expression responses in the ABPA group compared to the control groups.ConclusionsMultiple SNPs are now associated with ABPA. Some are novel associations. These associations implicate cytokine pathways and receptors in the aberrant response to A. fumigatus and susceptibility to ABPA, providing insights into the pathogenesis of ABPA and/or its complications. We hope these results will lead to increased understanding and improved treatment and diagnostics for ABPA.Electronic supplementary materialThe online version of this article (doi:10.1186/s13223-016-0152-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study

Overton

Denning

Bowyer

et al. 2016

Allergy Asthma Clin Immunol

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“…More recently, six of 21 Caucasian ABPA patients were found to be carriers of a CF mutation [2]. In further support of a possible genetic contribution there have been several reports of familial occurrence of ABPA [3–5].…”

Section: Introductionmentioning

confidence: 99%

Cystic fibrosis transmembrane conductance regulator gene mutations: do they play a role in the aetiology of allergic bronchopulmonary aspergillosis?

Eaton

Miller

Garrett

et al. 2002

Clin Experimental Allergy

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“…The familial occurrence of ABPA supports the same. 7 The HLA-DR molecules, especially DR2, DR5, and possibly DR4 and DR-7, are associated with susceptibility to ABPA, while HLA-DRQ2 has shown to have resistance to ABPA. Pulmonary infiltrates, when coupled with eosinophilia in an asthmatic subject, have raised an initial suspicion of some kind of eosinophilic lung disease such as ABPA, chronic eosinophilic pneumonia, or Churg-Strauss syndrome.…”

Section: Discussionmentioning

confidence: 99%

Allergic bronchopulmnary aspergillosis presenting with haemoptysis in a non asthmatic patient mimicking like tuberculosis.

2017

Int. J. Curr. Res. Med. Sci.

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Aspergillosis is the group of diseases caused by the Aspergillus species. Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitive disease showing various radiographic and clinical manifestations. Allergic bronchopulmonary aspergillosis (ABPA) is typically associated with asthma. Presence of asthma is one of the minimal essential diagnostic criteria for ABPA. Rarely, ABPA has been described in association with other diseases without asthma. We are presenting a case report of female patient who presented with haemoptysis due to allergic bronchopulmonary aspergillosis but without asthma.

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A familial occurrence of allergic bronchopulmonary aspergillosis: A probable environmental source

Cited by 13 publications

References 11 publications

Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study

Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study

Cystic fibrosis transmembrane conductance regulator gene mutations: do they play a role in the aetiology of allergic bronchopulmonary aspergillosis?

Allergic bronchopulmnary aspergillosis presenting with haemoptysis in a non asthmatic patient mimicking like tuberculosis.

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