A False-Positive Bone Oligometastatic Prostate Cancer in 18F-Choline PET/CT

Pretet, Valentin; Moreau, Aurélie; Larrouquere, Louis; Mognetti, Thomas; Kryza, David

doi:10.1097/rlu.0000000000004883

Clin Nucl Med

2023

DOI: 10.1097/rlu.0000000000004883

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A False-Positive Bone Oligometastatic Prostate Cancer in 18F-Choline PET/CT

Valentin Pretet,

Aurélie Moreau,

Louis Larrouquere

et al.

Abstract: We report the case of a 71-year-old man undergoing initial assessment for a high-risk group prostate adenocarcinoma. His medical history includes gastric carcinoma treated with surgery and chemotherapy. 18F-choline PET/CT was performed for initial staging and displayed several intense foci uptake of sternum and thoracic vertebrae, suggestive of bone metastasis. Because of a chronic right jugulosubclavian confluent thrombosis related to his implantable chamber, a control was performed 3 weeks later. It showed s… Show more

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2024

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Cited by 3 publications

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False-Positive Bone Pitfall Lesion and Collateral Circulation

Moreau,

Pretet,

Kryza

2024

Clin Nucl Med

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We report the case of a patient followed up for squamous cell carcinoma of the buccal floor with lymph node involvement. The initial staging PET/CT revealed bone foci that were not definitively pathological in the context of a regional collateral circulation secondary to a defibrillator. A new monitoring examination, conducted due to the rapid local progression, revealed a dissociated evolution of the bone uptake adjacent to the collateral circulation, some confirming false-positives, but one indicating a real metastasis. This case illustrates that bone uptakes without morphological lesions adjacent to a collateral circulation are not easily interpretable.

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False-Positive Bone Pitfall Lesion and Collateral Circulation

Moreau,

Pretet,

Kryza

2024

Clin Nucl Med

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False-Positive Bone Lesion With Different PET/CT Tracers

Moreau,

Pretet,

Kryza

2024

Clin Nucl Med

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Collateral circulation is often secondary to a regional thrombosis. This phenomenon can lead to the detection of misleading bone lesions on imaging and is a well-known source of false-positives. Here, we present 2 different tracers PET/CT images, 18F-FDG and 18F-choline, with collateral circulation but without obvious thrombosis. Both cases displayed bone uptake, which mimicked metastasis. However, clinical follow-up ruled out metastasis and revealed false-positive bone lesions related to collateral circulation, even in the lack of acute or chronic underlying thrombotic processes.

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Analysis of vascular thrombus and clinicopathological factors in prognosis of gastric cancer: A retrospective cohort study

Chen,

Ren,

Gao

et al. 2024

World J Gastrointest Oncol

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BACKGROUND Gastric cancer (GC) is one of the most common malignant tumors in the world, and its prognosis is closely related to many factors. In recent years, the incidence of vascular thrombosis in patients with GC has gradually attracted increasing attention, and studies have shown that it may have a significant impact on the survival rate and prognosis of patients. However, the specific mechanism underlying the association between vascular thrombosis and the prognosis of patients with GC remains unclear. AIM To analyze the relationships between vascular cancer support and other clinicopathological factors and their influence on the prognosis of patients with GC. METHODS This study retrospectively analyzed the clinicopathological data of 621 patients with GC and divided them into a positive group and a negative group according to the presence or absence of a vascular thrombus. The difference in the 5-year cumulative survival rate between the two groups was compared, and the relationships between vascular cancer thrombus and other clinicopathological factors and their influence on the prognosis of patients with GC were analyzed. RESULTS Among 621 patients with GC, the incidence of vascular thrombi was 31.7% (197 patients). Binary logistic regression analysis revealed that the degree of tumor differentiation, depth of invasion, and extent of lymph node metastasis were independent influencing factors for the occurrence of vascular thrombi in GC patients (P < 0.01). The trend of the χ 2 test showed that the degree of differentiation, depth of invasion, and extent of lymph node metastasis were linearly correlated with the percentage of vascular thrombi in GC patients (P < 0.01), and the correlation between lymph node metastasis and vascular thrombi was more significant (r = 0.387). Univariate analysis revealed that the 5-year cumulative survival rate of the positive group was significantly lower than that of the negative group (46.7% vs 73.3%, P < 0.01). Multivariate analysis revealed that age, tumor diameter, TNM stage, and vascular thrombus were independent risk factors for the prognosis of GC patients (all P < 0.05). Further stratified analysis revealed that the 5-year cumulative survival rate of stage III GC patients in the thrombolase-positive group was significantly lower than that in the thrombolase-negative group (36.1% vs 51.4%; P < 0.05). CONCLUSION Vascular cancer status is an independent risk factor affecting the prognosis of patients with GC. The combination of vascular cancer suppositories and TNM staging can better judge the prognosis of patients with GC and guide more reasonable treatment.

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A False-Positive Bone Oligometastatic Prostate Cancer in 18F-Choline PET/CT

Cited by 3 publications

References 8 publications

False-Positive Bone Pitfall Lesion and Collateral Circulation

False-Positive Bone Pitfall Lesion and Collateral Circulation

False-Positive Bone Lesion With Different PET/CT Tracers

Analysis of vascular thrombus and clinicopathological factors in prognosis of gastric cancer: A retrospective cohort study

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