A Factorial Approach for Optimizing the Design Parameters of a Tissue Attachment Mechanism for Drug Delivery

Sarker, Sunandita; Wankum, Benjamin; Shimizu, Jeff; Jones, Ryan M.; Terry, Benjamin S.

doi:10.1109/tbme.2021.3086975

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…One way this could be achieved would be by incorporating microneedles that penetrate the mucosa and are capable of average in vivo attachment times of up to 32 hours. 57 Further improvements may be obtained from barbed microneedles. 58 However, the long-term safety of microneedles penetrating the mucosa for extended periods has yet to be confirmed.…”

Section: Oral Drug Deliverymentioning

confidence: 99%

Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges

Borenstein,

Cummins,

Dutta

et al. 2023

Lab Chip

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Section: Oral Drug Deliverymentioning

confidence: 99%

Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges

Borenstein,

Cummins,

Dutta

et al. 2023

Lab Chip

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“…Achieving precise drug delivery can effectively improve the efficacy of the drug at the target site and reduce unnecessary systemic effects. Compared with pH responsive capsule robots [143], [144], magnetically actuated capsule robots have higher controllability and accuracy for drug delivery.…”

Section: Therapeuticsmentioning

confidence: 99%

Magnetically Actuated Capsule Robots: A Review

2022

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Capsule endoscopy is a procedure that uses a tiny wireless camera inside a capsule endoscope to take pictures of patient's gastrointestinal tract for diagnosis. Gastrointestinal examination has been revolutionized by capsule endoscope for its simplicity and non-invasiveness. However, at this stage, the capsule endoscope has weak controllable locomotion capability, and does not have extended functions such as biopsy, localization, and therapeutics, which has become the main obstacle to expanding its application. Using an external magnetic field to actuate the capsule endoscope has the advantages of simple response structure inside the capsule and remote energy supply, which can expand the above-mentioned functions of the capsule endoscope and develop into a multifunctional capsule robot. This paper analyzes two types of magnetic actuation systems for magnetically actuated capsule robots, discusses the research on the functions of magnetically actuated capsule robots in active locomotion, anchoring, biopsy, localization, therapeutics, wireless power supply, and multi-capsule robot collaboration, and points out the existing problems and future development directions of magnetically actuated capsule robots.INDEX TERMS Gastrointestinal tract, magnetically actuated, capsule endoscopy, capsule robot. FIGURE 1. A Schematic of the GI tract.

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Section: Epithelial Penetrationmentioning

confidence: 99%

“…In addition to these capsules, other devices currently being developed that propose to use microneedles for oral drug delivery include the tissue attachment capsule developed at the University of Nebraska [110] and the magnetically actuated microneedle capsule from Daegu Gyeongbuk Institute of Science and Technology, Korea [111]. The tissue attachment capsule from the University of Nebraska is being commercialised by Progenity Inc [110]. This capsule incorporates a tissue attachment module (TAM), consisting of a radial array of microneedles inspired by the design of intestinal parasites that is intended for the attachment of a drugcarrying payload that separates from the capsule.…”

Section: Epithelial Penetrationmentioning

confidence: 99%

“…This capsule incorporates a tissue attachment module (TAM), consisting of a radial array of microneedles inspired by the design of intestinal parasites that is intended for the attachment of a drugcarrying payload that separates from the capsule. Though ex vivo and in vivo studies have been conducted to optimise the reliability of the TAM in attaching to the intestinal mucosa for an extended period [110] [112], no studies have been published to date that demonstrate this technology for drug delivery.…”

Section: Epithelial Penetrationmentioning

confidence: 99%

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