The first results are reported on ͑ 6 He, 8 Be͒ two-proton pick-up reactions on 12 C, 16 O, and 19 F nuclei. The measurements were done with an 18 MeV beam on 6 LiF, 7 LiF, 6 Li 2 CO 3 , and 12 C targets. The measured angular distributions for the 12 C͑ 6 He, 8 Be͒ 10 Be (g.s.) and 12 C͑ 6 He, 8 Be͒ 10 Be * ͑3.37 MeV͒ reactions show a clear signature of a direct process. Although the contributions from the 6 Li͑ 6 He, 8 Be͒ 4 H reaction were observed, no clear extraction of the 4 H data was possible.