A facile synthesis of novel tricyclic 4-pyridones

Xu, Buzhe; Cheng, Zhixing; Fu, Lei

doi:10.1016/j.tetlet.2014.11.003

Cited by 7 publications

(1 citation statement)

References 25 publications

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“…In 2014, Fu et al 57 have described a new and efficient synthesis of 2-chloro-isoindolo[2,1-a]quinoline-5(11H)-one (47) through the intramolecular Heck coupling cyclization of 1-(2bromobenzyl)-7-chloroquinolin-4(1H)-one (46). The reaction was carried out by heating 46 (1 equiv.)…”

Section: Synthesis Of Tetracyclic Quinolinesmentioning

confidence: 99%

Advancements in the synthesis of fused tetracyclic quinoline derivatives

et al. 2020

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Section: Synthesis Of Tetracyclic Quinolinesmentioning

confidence: 99%

Advancements in the synthesis of fused tetracyclic quinoline derivatives

et al. 2020

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Transition Metal‐Catalyzed CH Functionalization of 2‐Pyridones, 2‐Pyrones, and Their Benzo‐Fused Congeners

Yamamoto

2022

Handbook of CH-Functionalization

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2‐Pyridone, 2‐pyrone, and their benzo‐fused congeners are privileged heterocyclic scaffolds that are widely found in natural products and drug molecules. The late‐stage functionalization of CH bonds in these heterocyclic scaffolds has been an important research area in synthetic organic chemistry as they provide straightforward and easy access to valuable bioactive derivatives. This article outlines transition metal‐catalyzed CH functionalizations of 2‐pyridones, 2‐pyrones, and their benzo‐fused congeners. It can be classified into several major categories in terms of the methodologies involved: (i) intermolecular CH functionalization without the directing groups, (ii) intermolecular CH functionalization using directing groups, and (iii) intramolecular CH functionalization.

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Transition Metal‐Catalysed Direct C−H Bond Functionalizations of 2‐Pyridone Beyond C3‐Selectivity

Biswas

Maity

Pan

et al. 2020

Chemistry An Asian Journal

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Abstract2‐Pyridone is a ubiquitous motif in natural products, drug molecules, ligands in catalysis and organic materials. There is a necessity of direct step‐economic methods for the construction of 2‐pyridone based molecules. Strategically, the primary developments have led to the C3‐functionalizations due to the inherent reactivity of this center. Despite this, many elegant transition metal‐catalysed methods have been established to introduce versatile functional groups at the C4, C5 and C6‐position via direct C−H bond functionalizations. This minireview focuses on the categorized introduction of different functional groups at the 2‐pyridone scaffolds beyond C3‐selectivity and discusses substrate scope, limitations and plausible mechanistic details.

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A facile synthesis of novel tricyclic 4-pyridones

Cited by 7 publications

References 25 publications

Advancements in the synthesis of fused tetracyclic quinoline derivatives

Advancements in the synthesis of fused tetracyclic quinoline derivatives

Transition Metal‐Catalyzed CH Functionalization of 2‐Pyridones, 2‐Pyrones, and Their Benzo‐Fused Congeners

Transition Metal‐Catalysed Direct C−H Bond Functionalizations of 2‐Pyridone Beyond C3‐Selectivity

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