A facile synthesis of label-free carbon dots with unique selectivity-tunable characteristics for ferric ion detection and cellular imaging applications

Chan, Kok Ken; Yang, Chengbin; Chien, Yi-Hsin; Panwar, Nishtha; Yong, Ken‐Tye

doi:10.1039/c8nj06306k

Cited by 49 publications

(38 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nowadays, most of reported N-CDs focuses on heavy metals detection under natural conditions. It is well known that the PL response of N-CDs is unstable in an acidic environment, limiting their function in the field of environmental contamination and metal ions sensing 8 . On top of this, the aforementioned spectroscopic data confirmed that the obtained N-CDs involve –OH, –COO - and –NH functional groups around N-CDs edge.…”

Section: Resultsmentioning

confidence: 99%

“…This is owing to their feature of having outstanding optical properties, including excellent biocompatibility, tuneable photoluminescence, negligible toxicity, ease of production and resistance to photobleaching in comparison to QDs counterparts 5 – 7 . It is well known that QDs, for instance, tend to be decayed in the biological environment leading to a serious toxicity concern 8 .…”

Section: Introductionmentioning

confidence: 99%

“…In particular, the ferric ion (Fe 3+ ) commonly exists in the human body and environment. The excess of ferric can induce an acknowledged risk of diseases, such as liver damage, kidney failure, or even death 8,32 . For these reasons, it would be sensible to develop rapid analytical tools for the monitoring of Fe 3+ ions in aqueous system.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Fluorescent recognition of Fe3+ in acidic environment by enhanced-quantum yield N-doped carbon dots: optimization of variables using central composite design

Issa

Abidin

Sobri

et al. 2020

Sci Rep

View full text Add to dashboard Cite

A versatile synthetic approach for development of highly fluorescent nitrogen-doped carbon dots (n-cDs) from carboxymethylcellulose in the presence of linear polyethyleneimine (Lpei) has been developed. According to single factor method, central composite design incorporated with response surface methodology matrix was applied to find and model optimal conditions for the temperature (220-260 °C), duration (1-3 h) and LPEI weight (0.5-1.5%). The statistical results show that duration was the most significant parameter for efficient carbonization conversion rate in comparison with temperature and Lpei weight. the reduced cubic model (R 2 = 0.9993) shows a good correlation between the experimental data and predicted values. the optimal variables were temperature of 260 °C, duration of 2 h and LPEI weight of 1%. Under these conditions, quantum yield of up to 44% was obtained. The numerically optimized N-CDs have an average size of 3.4 nm with graphitic nature owing to the abundant amino species incorporated into the carbon core framework. the blue-green n-cDs possess emission dependent upon the solvent polarity, wide pH stability with enhanced emission in an acidic environment. Impressively, the N-CDs show long-shelf-life for up to 1 year with no noticeable precipitation. the n-cDs were able to recognize a high concentration of fe 3+ ions with a detection limit of 0.14 μM in acidic solution owing to the special coordination for Fe 3+ to be captured by electron-donating oxygen/ amino groups around n-cDs. Moreover, the n-cDs can also be used as a new kind of fluorescent ink for imaging applications. Carbon dots (CDs) are the latest member of fluorescent carbon nano-sized family. Typically, CDs are nearly spherical-shaped nanoclusters with sizes of less than 10 nm and consist of amorphous or crystalline cores with sp 2 carbon atoms 1. Since the first established work 2 , CDs have attracted a considerable focusing in the fields of wastewater treatment, photocatalysis, bioimaging, cancer therapy and chemical sensing 3,4. This is owing to their feature of having outstanding optical properties, including excellent biocompatibility, tuneable photoluminescence, negligible toxicity, ease of production and resistance to photobleaching in comparison to QDs counterparts 5-7. It is well known that QDs, for instance, tend to be decayed in the biological environment leading to a serious toxicity concern 8 .

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fluorescent recognition of Fe3+ in acidic environment by enhanced-quantum yield N-doped carbon dots: optimization of variables using central composite design

Issa

Abidin

Sobri

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Later, Shi et al reported a facile synthesis of LCQDs by the introduction of secondary amine groups into lignin through Mannich and Michael addition reactions followed by carbonization, milling and filtration. 89 The resulting LCQDs showed an excellent performance for the detection of iron ions (Fe 3+ ) in a wide range of concentrations (1-100 nM) and lower detection limits (8 nM) compared to those of other CQDs based on foodstuff precursors as is the case of citric acid (0.3 mM) 102 or red lentils (0.10 mM) 103 among others 104,105 (Fig. 4a and b).…”

Section: Sensor and Biosensing Applicationsmentioning

confidence: 97%

Lignin-based smart materials: a roadmap to processing and synthesis for current and future applications

2020

View full text Add to dashboard Cite

show abstract

“…Thus, microwave-assisted synthesis rises as a facile alternative since it is rapid, provides uniform heating and can be executed using a domestic microwave oven [84]. For instance, Chan et al [85] prepared nitrogen and sulfur co-doped CDs by subjecting a mixture of citric acid and thiourea in water to 6 min of microwave-assisted heat treatment. The resultant CDs were found to be responsive towards ferric ion and were employed as a sensitive and selective ferric ion sensor.…”

Section: Carbon Dotsmentioning

confidence: 99%

Carbon Allotrope-Based Optical Fibers for Environmental and Biological Sensing: A Review

Yap

Chan

Tjin

et al. 2020

Sensors

Self Cite

View full text Add to dashboard Cite

Recently, carbon allotropes have received tremendous research interest and paved a new avenue for optical fiber sensing technology. Carbon allotropes exhibit unique sensing properties such as large surface to volume ratios, biocompatibility, and they can serve as molecule enrichers. Meanwhile, optical fibers possess a high degree of surface modification versatility that enables the incorporation of carbon allotropes as the functional coating for a wide range of detection tasks. Moreover, the combination of carbon allotropes and optical fibers also yields high sensitivity and specificity to monitor target molecules in the vicinity of the nanocoating surface. In this review, the development of carbon allotropes-based optical fiber sensors is studied. The first section provides an overview of four different types of carbon allotropes, including carbon nanotubes, carbon dots, graphene, and nanodiamonds. The second section discusses the synthesis approaches used to prepare these carbon allotropes, followed by some deposition techniques to functionalize the surface of the optical fiber, and the associated sensing mechanisms. Numerous applications that have benefitted from carbon allotrope-based optical fiber sensors such as temperature, strain, volatile organic compounds and biosensing applications are reviewed and summarized. Finally, a concluding section highlighting the technological deficiencies, challenges, and suggestions to overcome them is presented.2 of 43 of target molecules or physical parameters. In some instances, surface-modified carbon allotropes also permit multi-parameter detection capabilities of carbon allotrope-based OFS [7]. As such, an insight into the recent advances of carbon allotrope-based OFS can serve as a guideline to develop an effective detection approach for emerging real-world applications. Many review articles on carbon allotrope-based OFS mainly focus on a single type of carbon allotrope and the fundamental theory of carbon allotrope-based OFS [8,9]. Thus, this comprehensive review article encompasses the properties, preparation, sensing mechanisms, nanocoating deposition techniques, physical and biochemical sensing applications. This review aims to highlight the recent research work on carbon allotrope-based OFS that will serve as a reference guide for researchers to develop optimal detection approaches for physical parameters or trace level monitoring of chemical and biomolecules. Four groups of carbon allotropes, including carbon nanotubes (CNT), carbon dots (CDs), graphene, and nanodiamonds (NDs), will be studied. Commonly adopted synthesis approaches, classification of various deposition techniques for the integration of carbon allotropes as the thin film coating of OFS as well as numerous examples of these carbon allotrope-based OFS will also be outlined.

show abstract

A facile synthesis of label-free carbon dots with unique selectivity-tunable characteristics for ferric ion detection and cellular imaging applications

Abstract: The application of a pH-tuning concept to create specific analytical responses of carbon dots towards a specific targeted metal ion.

Cited by 49 publications

References 60 publications

Fluorescent recognition of Fe3+ in acidic environment by enhanced-quantum yield N-doped carbon dots: optimization of variables using central composite design

Fluorescent recognition of Fe3+ in acidic environment by enhanced-quantum yield N-doped carbon dots: optimization of variables using central composite design

Lignin-based smart materials: a roadmap to processing and synthesis for current and future applications

Carbon Allotrope-Based Optical Fibers for Environmental and Biological Sensing: A Review

Contact Info

Product

Resources

About