A facile synthesis and thio-Claisen rearrangement of 3-aryl-2-phenyl-5-prop-2-ynylsulfanyl-3H-pyrimidin-4-ones: regioselective transformation to thieno[3,2-d]pyrimidin-4-ones

Synthesis and biological activity of novel antibacterial quinazolines

“…Quinazolines exhibit a wide range of activity such as anthelmintic, 8 antimicrobial, [9][10][11] CNS depressant, 12 neuroleptic, 13 hypnotic 14 and analgesic. 15 In continuation of our work on heterocycles [16][17][18][19][20] with biological interest, we wish to report here in some new title quinazolines in order to study their antibacterial activities.…”

Selenium‐Containing Heterocycles from Isoselenocyanates: 4‐Methylselenazole Derivatives from the Reaction with Malononitrile and Propargyl Chloride

“…For example, propargyl bromides were used for the preparation of fused bicyclic systems like selenazolo [2,3- [22], and thieno-[3,2-d]-pyrimidin-4-ones were prepared via a thio-Claisen rearrangement of 5-(propargylsulfanyl)pyrimidin-4(3H)-ones [23]. The reactions of isocyanates with propargyl amine and propargyl alcohol led to 4-methylidenimidazolidin-2-ones and -1,3-oxazolidin-2-ones, respectively [24], whereas isothiocyanates and 3-methylbut-1-yn-3-ol by treatment with NaH yielded 4-methylidene-5,5-dimethyl-1,3-oxazolidine-2-thiones [25].…”

Synthesis and antifungal activities of 3,5‐diphenyl‐7‐amino‐[1,3]‐thiazolo[3,2‐a]pyrimidine‐6‐nitrile derivatives

“…Many of these derivatives are playing continually expanding roles in the development of different areas of chemistry, industry, pharmacology, and medicines . Pyrimidine and its derivatives show very promising response towards organic chemists because of their reported broad range of biological activity and medicinal importance . The fusion of pyrimidine moiety with heterocyclic nuclei enhances the biological activity many folds more than the parent nuclei.…”

“…derivatives show very promising response towards organic chemists because of their reported broad range of biological activity and medicinal importance. [9] The fusion of pyrimidine moiety with heterocyclic nuclei enhances the biological activity many folds more than the parent nuclei. Fused pyrimidines have become a considerable interest during the last 30 years.…”