A Facile Strategy for the Construction of Purely Organic Optical Sensors Capable of Distinguishing D<sub>2</sub>O from H<sub>2</sub>O

Luo, Yanju; Li, Chuan; Zhu, Wencheng; Zheng, Xujun; Huang, Yan; Lu, Zhiyun

doi:10.1002/anie.201900806

Cited by 40 publications

(37 citation statements)

References 42 publications

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“…The emission wavelength was shifted to longer wavelength (562 nm) by the formation of O − group (DDT‐F − ), which became a stronger donor in the benzene ring (Figure S5). Taking into account that the electron‐donating ability of oxygen anion is much higher than that of hydroxy group, the long‐wavelength emission band in DDT‐F − could be attributed to its phenolate anion species via facilitated intramolecular charge transfer, as reported earlier …”

Section: Resultssupporting

confidence: 54%

A Single‐Benzene‐Based Fluorophore: Optical Waveguiding in the Crystal Form

Cho

Choi

et al. 2019

ChemPlusChem

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A single‐benzene‐based, blue‐emissive diethyl 2,5‐dihydroxyterephthalate (DDT) was prepared by Fischer esterification of 2,5‐dihydroxyterephthalic acid (DHT) and ethanol. The strong fluorescence in both the solution and the solid state from such a simple framework stemmed from the push‐pull structure of the electron‐donating hydroxy groups and the accepting carbonyl groups, as well as structural planarity from intramolecular hydrogen bonds. The strong intermolecular hydrogen bonds enabled DDT to crystallize easily. The color CCD imaging technique showed efficient 1D optical waveguiding with a large optical loss coefficient of 0.15 dB/μm. DDT has potential application in optical sensors, photonic devices, and optoelectronic communication, because of its highly ordered structure and light‐emitting ability.

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Section: Resultssupporting

confidence: 54%

A Single‐Benzene‐Based Fluorophore: Optical Waveguiding in the Crystal Form

Cho

Choi

et al. 2019

ChemPlusChem

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“…However, because of the worse solubility in the aqueous phase, the detection is processed in the solid–liquid interface, and the relatively complicated physical-interaction-based responding mechanism makes it difficult to design D 2 O optical probes deliberately. Recently, Lu and co-workers disclosed the D 2 O optical sensors by small organic molecules of NIM-2F and AF, and the sensing mechanism is ascribed to the small difference in acidity between H 2 O and D 2 O. The responses toward H 2 O and D 2 O are quite different, and the LOD of AF toward D 2 O in H 2 O content is determined to be as low as 89 ppm.…”

Section: Resultsmentioning

confidence: 99%

Facile Polymerization Strategy for the Construction of Eu³⁺-Based Fluorescent Materials with the Capability of Distinguishing D₂O from H₂O

et al. 2020

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Aggregation-induced emission (AIE) and antenna effect (AE) are two important luminescence behaviors. Connecting them into polymers is a promising but challenging work, which can supply opportunities for luminescence materials with extensive applications. In this work, AIE-active Eu3+-coordinated polymers (Poly-Eu-1, -2, -3, and -4) have been synthesized, and the efficient AE was verified. This finding presents a facile approach to obtain the Ln3+-based solid luminescence materials due to the synergistic effect from AIE and AE. Also, benefiting from the film-processing ability and water solubility, Poly-Eu-1, -2, -3, and -4 could be employed with different application purposes. In the solution phase, they can be used as sensitive optical probes to detect trace amounts of H2O and D2O, and the limit of detection (LOD) of Poly-Eu-2 toward D2O in H2O is determined to be 7.8 ppm. This discovery is a novel strategy for the construction of D2O optical sensors with a totally intervention-free style.

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“…However, the literature has seen little exploration regarding the engineering of the MOF structure properties to regulate the dynamic ranges and sensitivities of MOF‐based probes, though they have been widely investigated and developed for detecting various analytes. [ 18–30 ] Moreover, only a few of these MOF‐based sensors are used for recognizing disease‐related markers, [ 23,24,28 ] and they are also limited to an unoptimizable detection range with insufficient responses to small changes of the targets concentration, which is unsatisfactory for precise diagnosis of disease. Herein, we report a novel strategy to engineer a luminescent lanthanide‐based metal–organic framework (Eu‐ZnMOF) biosensor with tunable detection performances for tracing the overexpressed VMA in urine ( Scheme ).…”

Section: Methodsmentioning

confidence: 99%

Structure Engineering of a Lanthanide‐Based Metal–Organic Framework for the Regulation of Dynamic Ranges and Sensitivities for Pheochromocytoma Diagnosis

Hao

Niu

et al. 2020

Advanced Materials

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Exploring innovative technologies to precisely quantify biomolecules is crucial but remains a great challenge for disease diagnosis. Unfortunately, the humoral concentrations of most biotargets generally vary within rather limited scopes between normal and pathological states, while most literature‐reported biosensors can detect large spans of targets concentrations, but are less sensitive to small concentration changes, which consequently make them mostly unsatisfactory or even unreliable in distinguishing positives from negatives. Herein, a novel strategy of precisely quantifying the small concentration changes of a certain biotarget by editing the dynamic ranges and sensitivities of a lanthanide‐based metal–organic framework (Eu‐ZnMOF) biosensor is reported. By elaborately tailoring the biosensor's structure and surface areas, the tunable Eu‐ZnMOF is developed with remarkably enhanced response slope within the “optimized useful detection window,” enabling it to serve as a powerful signal amplifier (87.2‐fold increase) for discriminating the small concentration variation of urinary vanillylmandelic acid (an early pathological signature of pheochromocytoma) within only three times between healthy and diseased subjects. This study provides a facile approach to edit the biosensors' performances through structure engineering, and exhibits promising perspectives for future clinical application in the non‐invasive and accurate diagnosis of severe diseases.

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A Facile Strategy for the Construction of Purely Organic Optical Sensors Capable of Distinguishing D₂O from H₂O

Cited by 40 publications

References 42 publications

A Single‐Benzene‐Based Fluorophore: Optical Waveguiding in the Crystal Form

A Single‐Benzene‐Based Fluorophore: Optical Waveguiding in the Crystal Form

Facile Polymerization Strategy for the Construction of Eu³⁺-Based Fluorescent Materials with the Capability of Distinguishing D₂O from H₂O

Structure Engineering of a Lanthanide‐Based Metal–Organic Framework for the Regulation of Dynamic Ranges and Sensitivities for Pheochromocytoma Diagnosis

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A Facile Strategy for the Construction of Purely Organic Optical Sensors Capable of Distinguishing D2O from H2O

Cited by 40 publications

References 42 publications

A Single‐Benzene‐Based Fluorophore: Optical Waveguiding in the Crystal Form

A Single‐Benzene‐Based Fluorophore: Optical Waveguiding in the Crystal Form

Facile Polymerization Strategy for the Construction of Eu3+-Based Fluorescent Materials with the Capability of Distinguishing D2O from H2O

Structure Engineering of a Lanthanide‐Based Metal–Organic Framework for the Regulation of Dynamic Ranges and Sensitivities for Pheochromocytoma Diagnosis

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A Facile Strategy for the Construction of Purely Organic Optical Sensors Capable of Distinguishing D₂O from H₂O

Facile Polymerization Strategy for the Construction of Eu³⁺-Based Fluorescent Materials with the Capability of Distinguishing D₂O from H₂O