“…Hydrogenolysis of a-hydrazino acid derivatives that are N 1 ,N 2 -unsubstituted or substituted by aryl or alkyl substituents also occurs using palladium hydroxide [181] or platinum [190] [190] 64j 2 Synthesis and Chemistry of a-Hydrazino Acids LiOAc/AcOH mixture at pH 7-8 [195] 66j 2 Synthesis and Chemistry of a-Hydrazino Acids oxide [108,110,188,193]. Hydrogen and palladium on charcoal are selective for benzyl or benzyloxycarbonyl groups and are generally unable to cleave NÀN bonds [59,68,109,111,156,173], except in the case of aminoserine, which has been converted to serine [165]. Hydrogen and palladium on charcoal are selective for benzyl or benzyloxycarbonyl groups and are generally unable to cleave NÀN bonds [59,68,109,111,156,173], except in the case of aminoserine, which has been converted to serine [165].…”