A facile Pd(II)-mediated synthesis of bicyclo[3.3.1]nonadienones

Stereocontrolled Synthesis and Reactions of Bicyclo[3.3.1]nonanes

“…The ring closure is regarded as proceeding by nucleophilic attack of the enol ether double bond on Pd(II)-complexed exocyclic olefin. 29 This synthesis started with the Birch reduction of substituted benzoic acid followed by allylation of the resulting cyclohexadiene acid dianion.…”

Total regiospecific synthesis of the selagine tricyclic ring system

“…The total synthesis of selagine (I), a Lycopodium alkaloid whose structure was determined over twenty years ago by Wiesner, Valenta, and co-workers (I), still remains an open challenge in the literature and recent publications which have appeared (2)(3)(4)(5) attest to the interesting problems of regiochemistry posed by this molecule.…”

Palladium(II) Acetate

“…3.1]nonadienones92 and to a total synthesis of quadrone. 93 as stoichiometric oxidant in acetic acid leads to an oxidative cyclization reaction (eqs 46 and 47).…”