A Facile One-Step Conversion of Chalcones into 2,3-Dihydroflavonols

Efficient conversion of 2′-hydroxychalcones into flavanones and flavanols in a water suspension medium

“…7,8 We have found that the conversion of 1a into 3a proceeds more efficiently in a water suspension medium and the products are isolated simply by filtration. For example, a suspension of a mixture of powdered 2A-hydroxychalcone 1a (0.10 g, 0.45 mmol), an aq.…”

Crystal structure of (2S/2R,3S/3R)-3-hydroxy-2-phenylchroman-4-one

“…For the synthesis and applications of flavone derivatives, see: Gaspar et al (2014); Huang et al (2007); Yu et al (2003); Phosrithong et al (2012); Harborne & Williams (2000); Tanaka & Sugino (2001); Saxena et al (1985). For the synthesis of the title compound, see: Juvale et al (2013).…”

“…On the other hand, the Algar, Flynn and Oyamada (AFO) oxidation of substituted 2′-hydroxychalcones with alkaline hydrogen peroxide give flavonol derivatives (Juvale et al, 2013). Dihydroflavonol was also obtained by this reaction (Saxena et al, 1985;Tanaka & Sugino (2001). In this paper, we report the structure determination of the title compound resulting from the oxidation of 2′-hydroxychalcone using AFO reaction conditions.…”

Synthetic Studies Towards the Preparation of 2‐Benzyl‐2‐hydroxybenzofuran‐3(2H)‐one, the Prototype of Naturally Occurring Hydrated Auronols.

“…178 ± 1808 ( [14]: 1788). A mixture of 1 (2 g, 8.9 mmol), Et 2 NH (3.25 g, 44.5 mmol), and dioxane (135 ml) was stirred at 0 ± 58.…”