A Facile One-Pot Synthesis of Benzimidazole-Linked Pyrrole Structural Motifs <i>via</i> Multicomponent Approach: Design, Synthesis, and Molecular Docking Studies

Chedupaka, Raju; Venkatesham, Papisetti; Sangolkar, Akanksha Ashok; Vedula, Rajeswar Rao

doi:10.1080/10406638.2021.1995010

Cited by 5 publications

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The main moto of green chemistry is to use or create substances causing less or no toxicity to the human health and environment. Hence, the modern chemist has been paid their attention on environment ecofriendly reactions like, solvent-free [1], water-medium [2], microwave irradiated [3], and multicomponent reactions [4][5][6][7] are using in ultramodern synthesis. Among aforementioned, multicomponent reactions (MCRs) are forefront of the present research trend in ultramodern synthesis.…”

Section: Introductionmentioning

confidence: 99%

One-pot, three-component synthesis, anti-bacterial and molecular modelling studies of novel benzimidazole based isoindoline-1,3-dione and benzo[4,5]imidazo[2,1-b]thiazol hybrids

Chedupaka

Shyam

Mamidala

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

A series of metal-free, thioalkylated benzimidazole-based isoindoline-1,3-dione (4a-w) and N-fused 4,5-benzo[4,5]imidaz[2,1-b]thiazole (5a-h) derivatives were synthesized via a novel, one-pot three-component approach. All the synthesized scaffolds were well characterized by analytical and spectroscopic techniques. The usefulness of this reaction is that it involves easy workup, shorter reaction time, broad substrate scope, and column-free purification of the products. Further, the synthesized scaffolds (4a-w) were evaluated for their in-vitroanti-microbial activity using two Gram-positive and two Gram-negative bacterial cell lines Escherichia coli, Salmonella typhi, Staphylococcus aureus and Micrococcus luteus by agar well diffusion method. Among tested compounds, compounds 4a, 4g, 4j, 4q, 4s, and 4t showed significant invitro antibacterial activity against Gram-positive and Gram-negative bacterial cell lines. Further, we have also insight of molecular docking studies, based on the docking results compounds 4s, 4j, 4a, 4q, 4t, and 4g have shown stable binding interaction with streptomycin drug with active site of the B-DNA (PDB ID: 1BNA). The antibacterial activity, and molecular docking studies of the title compounds were suggested that these are promising anti-bacterial active skeletons.

show abstract