A Facile One‐Pot Solvent‐Free Synthesis, in Vitro and in Silico Studies of a Series of Tetrahydropyridine Derivatives as Breast Cancer Inhibitors
Ramasamy Duraisamy,
Prashantha Nagaraja,
Aatika Nizam
et al.
Abstract:Ammonium trifluoroacetate (ATA) catalysed synthesis of 1,2,5,6‐tetrahydropyridine (THP) derivatives, under eco‐friendly conditions via a facile one‐pot strategy. We have synthesized fifteen THP derivatives, and docked into the crystal structure of Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) tumour suppressor protein (PDB ID: 1D5R) based on drug‐likeness prediction and pharmacokinetic properties. Molecular docking simulation studies reveal that four of our synthesised compounds are potential … Show more
By exploring the photo catalytic activity of rose bengal (RB) encapsulated on zeolitic imidazolate framework (ZIF-8) under visible light irradiation, we have developed a unique approach for the synthesis of...
By exploring the photo catalytic activity of rose bengal (RB) encapsulated on zeolitic imidazolate framework (ZIF-8) under visible light irradiation, we have developed a unique approach for the synthesis of...
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