“…3 They also exerts in vitro antiproliferative effect on a number of different human cell lines. 4,5 As for the pharmacodynamic mechanism, brassinin and its derivatives are inhibitors of indolamine 2,3-dioxygenase, a new cancer immunosuppression target. 6 Izutani et al revealed, that brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signalling pathway in human colon cancer cells.…”