A facile method for monitoring solid-phase peptide synthesis and for N-terminal modification of peptides: synthesis of short peptides for imaging specific cells

Rajavenkatesh, K; Santoshkumar, S.; Purnasai, K; Thennarasu, Sathiah

doi:10.1007/s12039-019-1683-9

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…A naked-eye detection of the free amino group has been tested by Rajavenkatesh et al [37] using solidphase peptide synthesis. It is a catalytic cyclisation technique of 2-(2-oxo-2H-acenaphthylene-1-ylidene)malononitrile and oxidative substitution of aryl moiety by free amine group existing in N-terminal position of the peptide chain.…”

Section: Synthesis Of Peptide and Proteinsmentioning

confidence: 99%

An overview of recent progress in modern synthetic approach—combinatorial synthesis

Gopi¹,

Krupamai²,

Sri³

et al. 2020

Beni-Suef Univ J Basic Appl Sci

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Background In recent times, a powerful tool of combinatorial synthesis has been used for the preparation of large chemical entities through a small set up of reactions between different building blocks using solid-phase and solution-phase techniques. This method reduced the time and cost of the drug discovery process substantially. Main text Thousands of compounds are synthesised in a few reactions through combinatorial synthesis instead of getting a few compounds in the traditional method. This method also helps to identify chemical lead of the compounds and optimise them through the biological screening using a high-throughput method. There is no review concerning the recent research finding of combinatorial synthesis. Hence, an attempt had been made on the latest research findings (2002–2020) of newly synthesised compounds using combinatorial synthesis and their biological activities. Conclusion To the best of our knowledge, the current review has completely analysed the importance of combinatorial synthesis and furnished an overview of solid-phase and solution-phase techniques as well as helped mankind by improving higher productivity at low cost, lead identification and optimization and preventing environmental pollution. Graphical abstract

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Section: Synthesis Of Peptide and Proteinsmentioning

confidence: 99%

An overview of recent progress in modern synthetic approach—combinatorial synthesis

Gopi¹,

Krupamai²,

Sri³

et al. 2020

Beni-Suef Univ J Basic Appl Sci

View full text Add to dashboard Cite

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Design and Synthesis of certain Novel Peptides for Dual Selective Activity of Specific Cells

Paul

Ganesan

Jaisankar

2022

IJSRSET

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Cancer and the multi-resistant diseases that plague people today must be controlled to lower mortality rates. With the low susceptibility to resistance, the design and synthesis of peptide assembling was a superior alternative upgrading source for future chemotherapeutic medications. This paradigm first appeared in the pharmaceutical industry. It has been demonstrated that specific peptides exhibit dual functions as antibacterial and anticancer peptides (ACPs). Using a minimalized approach, a 10-residue peptide P1 and Rhodamine tagged peptide P2 were designed and synthesized using solid phase peptide synthesis method (SPPS) for selective activity against microbial and cancer cell lines. Peptide P1 contains RGD sequence has a net charge of +2 and peptide P2 has net charge of -4. The peptide P1 and P2 are characterized by using spectroscopic techniques. Circular dichroism studies showed changes in the secondary structure of peptide 1 and peptide 2 with buffer. Cytotoxicity assay exhibited the viability of normal and cancer cells up to 5 ?g concentrations of peptide 1.Thus, Peptide 1 acts on therapeutic properties like antibacterial and anticancer. Both peptide activities are checked against gram-positive and gram-negative bacteria at lower concentration. We can ensure the toxicity level of designed both peptides. Peptide P1 and peptide P2 sequence are non-toxic and recognition of selective activity against cancer cells.

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A facile method for monitoring solid-phase peptide synthesis and for N-terminal modification of peptides: synthesis of short peptides for imaging specific cells

Cited by 2 publications

References 16 publications

An overview of recent progress in modern synthetic approach—combinatorial synthesis

An overview of recent progress in modern synthetic approach—combinatorial synthesis

Design and Synthesis of certain Novel Peptides for Dual Selective Activity of Specific Cells

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