“…The in vivo assay demonstrated that the antibacterial BNC dressing could inhibit infection and inflammation and accelerate wound healing within 12 days compared with BNC. To reduce the cytotoxicity of sliver-based dressing and promote wound healing, a novel multifunctional sliver nanowires (AgNWs)/collagen I (Col I)/BNC dressing was constructed via compositing AgNWs into BNC and adsorbing Col I [50]. The antibacterial assay demonstrated that the multifunctional AgNWs/Col I/BNC dressing could kill S. ausreus and E. coli colonizing on the surface of material due to the silver ions released.…”
Unlike plant and wood-origin cellulose, bacterial nanocellulose (BNC) produced by bacteria exhibits the highest purity and natural nanofiber morphology, attracting increasing interest from many researchers and industrial sectors. It has numerous unique features including the biomimetic nanoscale three-dimensional (3D) network, high water holding capacity, and moldability in different shapes, accepted wet strength, outstanding gas permeability, and good biocompatibility, which makes the BNC show great potential in a wide variety of biomedical applications. Extensive research has verified the feasibility of application in wound dressing, bone/cartilage tissue regeneration, vascular tissue engineering, and so on. This chapter focuses on the production and properties of BNC, the fabrication of BNC-based biomaterials, and the biomedical applications of BNC.
“…The in vivo assay demonstrated that the antibacterial BNC dressing could inhibit infection and inflammation and accelerate wound healing within 12 days compared with BNC. To reduce the cytotoxicity of sliver-based dressing and promote wound healing, a novel multifunctional sliver nanowires (AgNWs)/collagen I (Col I)/BNC dressing was constructed via compositing AgNWs into BNC and adsorbing Col I [50]. The antibacterial assay demonstrated that the multifunctional AgNWs/Col I/BNC dressing could kill S. ausreus and E. coli colonizing on the surface of material due to the silver ions released.…”
Unlike plant and wood-origin cellulose, bacterial nanocellulose (BNC) produced by bacteria exhibits the highest purity and natural nanofiber morphology, attracting increasing interest from many researchers and industrial sectors. It has numerous unique features including the biomimetic nanoscale three-dimensional (3D) network, high water holding capacity, and moldability in different shapes, accepted wet strength, outstanding gas permeability, and good biocompatibility, which makes the BNC show great potential in a wide variety of biomedical applications. Extensive research has verified the feasibility of application in wound dressing, bone/cartilage tissue regeneration, vascular tissue engineering, and so on. This chapter focuses on the production and properties of BNC, the fabrication of BNC-based biomaterials, and the biomedical applications of BNC.
“…The skin is the largest organ in our body and plays a vital role in protecting internal organs, regulating body temperature, and maintaining the body's osmotic balance. [1][2][3] However, injuries to the skin can produce bleeding and excess biofluid, leading to bacterial infections, compromised wound healing, and even severe tissue damage. [4][5][6] Various hydrophilic or hydrophobic wound dressings have been developed.…”
Exudate management and bioelectric signals are critical to promoting wound healing. In this study, the thermoplastic polyurethane (TPU) nanofiber is directly electrospun on the cotton microfibers (Cotton) to prepare a Janus dressing (TPU/Cotton), which can unidirectionally drain the excess exudate. Then, Ag/Zn dot electrodes are deposited on the TPU layer, which can produce an electric field penetrating the wound when activated by wound exudate. The hydro‐activated Ag/Zn's electrical stimulation (ES) can promote the migration of fibroblast cells and shows excellent antibacterial activity against E. coli and S. aureus. Furthermore, in vivo experiments show that the exudate management coupled with ES accelerated wound healing at multiple stages by promoting re‐epithelization, collagen deposition, and vascularization. Moreover, the Ag/Zn@TPU/Cotton dressing shows excellent biocompatibility in the vitro cytotoxicity experiments. These findings may shed some light on developing the next generation of wound dressings with self‐activated electrical stimulation and exudate management.
“…Although there have been several reports on the combination of BC and AgNWs for wound healing, research on the application of ES in BC and AgNW composition has not been studied. [28,29] Since the birth of the concept of artificial intelligence (AI) proposed in 1956, convolutional neural networks (CNN) have been making major advances in medical field in recent years. [30] Medical images acquired with, for example, X-ray, computerized tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), histopathological examination, and ultrasonography were applied in digital pathology and cell imaging.…”
Section: Introductionmentioning
confidence: 99%
“…[ 27 ] Compared with silver nanoparticles, AgNWs have a higher length‐to‐diameter ratio and slower release of silver ions, resulting in a more sustained release and non‐toxicity. [ 28 ] Besides, the fibrous AgNWs do not affect pore structure within BC, which is important to maintain air permeability. [ 29 ] Therefore, AgNWs are suitable as antibacterial and conductive components to construct wound dressings.…”
Section: Introductionmentioning
confidence: 99%
“…Although there have been several reports on the combination of BC and AgNWs for wound healing, research on the application of ES in BC and AgNW composition has not been studied. [ 28,29 ]…”
Bandages for daily wounds are the most common medical supplies, but there are still ingrained defects in their appearance, comfort, functions, as well as environmental pollution. Here, novel bandages based on bacterial cellulose (BC) membrane for wound monitoring and advanced wound management are developed. The BC membrane is combined with silver nanowires (AgNWs) by using vacuum filtration method to achieve transparent, ultrathin (≈7 µm), breathable (389.98–547.79 g m−2 d−1), and sandwich‐structured BC/AgNWs bandages with superior mechanical properties (108.45–202.35 MPa), antibacterial activities against Escherichia coli and Staphylococcus aureus, biocompatibility, and conductivity (9.8 × 103–2.0 × 105 S m−1). Significantly, the BC/AgNWs bandage is used in the electrical stimulation (direct current, 600 microamperes for 1 h every other day) treatment of full‐thickness skin defect in rats, which obviously promotes wound healing by increasing the secretion of vascular endothelial growth factor (VEGF). The BC bandage is used for monitoring wounds and achieve a high accuracy of 94.7% in classifying wound healing stages of hemostasis, inflammation, proliferation, and remodeling, by using a convolutional neural network. The outcomes of this study not only provide two BC‐based bandages as multifunctional wound management, but also demonstrate a new strategy for the development of the next generation of smart bandage.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.