A facile atom economic one pot multicomponent synthesis of bioactive spiro-indenoquinoxaline pyrrolizines as potent antioxidants and anti-cancer agents

Abstract

One pot method for the synthesis of biologically active novel spiro-indenoquinoxaline pyrrolizines by means of four-component reaction between ninhydrin, o-phenylenediamine, l-proline and quinolinyl chalcones in methanol via [3+2] cycloaddition.

Trimethylglycine-Betaine-Based-Catalyst-Promoted Novel and Ecocompatible Pseudo-Four-Component Reaction for Regioselective Synthesis of Functionalized 6,8-Dihydro-1′H,5H-spiro[[1,3]dioxolo[4,5-g]quinoline-7,5′-pyrimidine]-2′,4′,6′(3′H)-trione Derivatives

“…In heterocyclic chemistry, nitrogen-containing spiro compounds show various pharmacological applications. 29,30 Some of them are used as anti-HIV, 31 antifungal, 32,33 anticancer, 34,35 antibacterial, 36 and cytotoxic agents. 37 In the present scenario, multicomponent reactions are promising tools for the construction of novel organic frameworks.…”

“…In heterocyclic chemistry, nitrogen-containing spiro compounds show various pharmacological applications. , Some of them are used as anti-HIV, antifungal, , anticancer, , antibacterial, and cytotoxic agents . In the present scenario, multicomponent reactions are promising tools for the construction of novel organic frameworks. − In our current study, we explored a novel one-pot reaction of 3,4-methylenedioxyaniline, N , N -dimethylbarbituric acid, and aldehydes.…”

Ru(II)-Catalyzed Switchable C–H Alkylation and Spirocyclization of 2-Arylquinoxalines with Maleimides via ortho-C–H Activation

“…In particular, indenoquinoxalines are privileged scaffolds that are featured in a wide variety of natural products and useful drug molecules (Figure ). , However, the synthetic methods for spirocyclic products usually suffer from the use of complex starting materials, limited substrate scope, or multistep operation . Therefore, the development of a more practical and general route for diverse construction of valuable spiro-indenoquinoxaline derivatives starting from simple substrates under mild reaction conditions remains in high demand.…”

Sequential Cu‐Catalyzed Four‐ and Five‐Component Syntheses of Luminescent 3‐Triazolylquinoxalines

“…[10] Quinoxalinesh ave become increasingly important due to variousi ntrinsic properties [11] and they can also be synthesized by MCR approaches. [12] In addition to the strongly electronwithdrawing nature of quinoxaline cores, the pyridyl nitrogen centers can be ideally addressed by pH change, [13] metal-ion coordination, [14] solvent-polarity changes, [12,13,15] or biological analytes. [16] Quinoxalines receive most interesta sb iologically active compounds [17] as well as functional chromophores.…”