A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery

Chai, Zhilan; Hu, Xuefeng; Wei, Xiaoli; Zhan, Changyou; Lu, Linwei; Jiang, Kuan; Su, Bingxia; Ruan, Huitong; Ran, Danni; Fang, Ronnie H.; Zhang, Liangfang; Lu, Weiyue

doi:10.1016/j.jconrel.2017.08.027

Cited by 182 publications

(125 citation statements)

References 37 publications

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“…Notably, at 24 h postinjection, both P1 NPs group and P1 RGD NPs group show high PA signals in tumor with a detectable depth up to 3.2 and 2.8 mm, respectively, which is in good agreement with the magnetic resonance imaging results. Importantly, at 24h postinjection, the P1 RGD NPs group shows a higher S/B of 90, which is much higher than that of 61 for NPs group, owing to the benefits of receptor mediated tumor cell uptake in the “ P1 RGD NPs” group, as compared to the EPR effect alone in the “ P1 NPs” group . The achieved S/B in this study is much higher than that of other reported results for PA imaging of orthotopic brain tumors, and far beyond the S/B threshold of 5 required in image‐guided surgery to clearly differentiate brain tumors from surrounding tissues …”

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confidence: 53%

“…To construct efficient brain tumor treatment paradigms, so far, most efforts have been devoted to developing advanced therapeutic systems such as chemo and gene therapy . These methods strongly rely on sophisticated design of drug delivery systems (DDS) to transport drug/gene into tumors and realize release in a controlled manner.…”

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confidence: 99%

“…These methods strongly rely on sophisticated design of drug delivery systems (DDS) to transport drug/gene into tumors and realize release in a controlled manner. However, the DDS accumulation in normal tissues often leads to unwanted side‐effects . In addition, GBM cells can rapidly develop drug resistance, which causes limitations of the available therapeutics .…”

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confidence: 99%

“…After THF evaporation, (c‐RGD) peptide, which actively targets α V β 3 integrin receptors over‐expressed in endothelial cells of the brain tumor angiogenic vasculatures as well as on glioblastoma cells, was covalently decorated on the P1 NP surface via Michael addition reaction to yield P1 RGD NPs (Figure a). The RGD decoration would enhance NP uptake inside tumors and result in improved imaging and therapy outcomes . Detailed analysis revealed that 45.3% of the surface maleimide groups were successfully reacted with the c‐RGD (Supporting Information).…”

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confidence: 99%

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Through Scalp and Skull NIR‐II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance

et al. 2018

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Brain tumor is one of the most lethal cancers owing to the existence of blood-brain barrier and blood-brain tumor barrier as well as the lack of highly effective brain tumor treatment paradigms. Herein, cyclo(Arg-Gly-Asp-D-Phe-Lys(mpa)) decorated biocompatible and photostable conjugated polymer nanoparticles with strong absorption in the second near-infrared (NIR-II) window are developed for precise photoacoustic imaging and spatiotemporal photothermal therapy of brain tumor through scalp and skull. Evidenced by the higher efficiency to penetrate scalp and skull for 1064 nm laser as compared to common 808 nm laser, NIR-II brain-tumor photothermal therapy is highly effective. In addition, via a real-time photoacoustic imaging system, the nanoparticles assist clear pinpointing of glioma at a depth of almost 3 mm through scalp and skull with an ultrahigh signal-to-background ratio of 90. After spatiotemporal photothermal treatment, the tumor progression is effectively inhibited and the survival spans of mice are significantly extended. This study demonstrates that NIR-II conjugated polymer nanoparticles are promising for precise imaging and treatment of brain tumors.

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confidence: 99%

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confidence: 99%

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Through Scalp and Skull NIR‐II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance

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“…Compared with their nontargeted counterparts, RGD‐functionalized nanoparticles had a fivefold higher accumulation at the tumor vasculature, which prolonged the survival of tumor‐bearing mice from 13 days to 21 days. Another biomimetic targeting ligand is the CDX peptide, which was synthesized with inspiration from candoxin, a snake neurotoxin that binds to nicotinic acetylcholine receptors on brain endothelial cells with high affinity and selectivity . Once bound, candoxin can subsequently be transported to brain cells through receptor‐mediated transcytosis .…”

Section: Biomimetic Nanoparticle Technologymentioning

confidence: 99%

Biomimetic Nanotechnology toward Personalized Vaccines

et al. 2019

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While traditional approaches for disease management in the era of modern medicine have saved countless lives and enhanced patient well‐being, it is clear that there is significant room to improve upon the current status quo. For infectious diseases, the steady rise of antibiotic resistance has resulted in super pathogens that do not respond to most approved drugs. In the field of cancer treatment, the idea of a cure‐all silver bullet has long been abandoned. As a result of the challenges facing current treatment and prevention paradigms in the clinic, there is an increasing push for personalized therapeutics, where plans for medical care are established on a patient‐by‐patient basis. Along these lines, vaccines, both against bacteria and tumors, are a clinical modality that could benefit significantly from personalization. Effective vaccination strategies could help to address many challenging disease conditions, but current vaccines are limited by factors such as a lack of potency and antigenic breadth. Recently, researchers have turned toward the use of biomimetic nanotechnology as a means of addressing these hurdles. Recent progress in the development of biomimetic nanovaccines for antibacterial and anticancer applications is discussed, with an emphasis on their potential for personalized medicine.

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Biomimetic Nanoparticle Vaccines for Cancer Therapy

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It is currently understood that, in order for a tumor to successfully grow, it must evolve means of evading immune surveillance. In the past several decades, researchers have leveraged increases in our knowledge of tumor immunology to develop therapies capable of augmenting endogenous immunity and eliciting strong antitumor responses. In particular, the goal of anticancer vaccination is to train the immune system to properly utilize its own resources in the fight against cancer. Although attractive in principle, there are currently only limited examples of anticancer vaccines that have been successfully translated to the clinic. Recently, there has been a significant push towards the use of nanotechnology for designing vaccine candidates that exhibit enhanced potency and specificity. In this progress report, we discuss recent developments in the field of anticancer nanovaccines. By taking advantage of the flexibility offered by nanomedicine to purposefully program immune responses, this new generation of vaccines has the potential to address many of the hurdles facing traditional platforms. A specific emphasis is placed on the emergence of cell membrane-coated nanoparticles, a novel biomimetic platform that can be used to generate personalized nanovaccines that elicit strong, multi-antigenic antitumor responses.

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A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery

Cited by 182 publications

References 37 publications

Through Scalp and Skull NIR‐II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance

Through Scalp and Skull NIR‐II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance

Biomimetic Nanotechnology toward Personalized Vaccines

Biomimetic Nanoparticle Vaccines for Cancer Therapy

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