A facile and practical Amination of 4-Fluoronitrobenzene in continuous flow

Process intensification of dendritic fibrous nanospheres of silica (DFNS) via continuous flow: a scalable and sustainable alternative to the conventional batch synthesis

“…61 The ATR is a commercially successful reactor in industries known to handle solid slurries and suspensions in addition to gas-liquid and solid-liquid-gas processes. [62][63][64][65][66][67] The unique tube-and-agitator design 68,69 has been proven to effectively circumvent pressure drops when connecting two or more reactors in series, thus enabling kilo-scale production with high throughput. Owing to these advantages, we decided to employ this scale-up tool for demonstrating the telescoped flow synthesis for the high-throughput production of DFNS.…”

Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides

“…In addition, reaction times are typically on the order of 12–24 h. Because of the low boiling point of methylamine, it is often necessary to perform the reaction under pressure in a sealed tube. Alternatively, a continuous flow process would be a powerful alternative, as shown in the synthesis of fluoxetine, whereby an alkyl iodide was converted into an N -methyl secondary amine. , Many advantages would be associated with the development of a general method combining the use of the aqueous methylamine reagent with the displacement of mesylates derived from alcohols. Not only would such a process take advantage of an inexpensive source of methylamine, but alcohols are also readily available and versatile reagents.…”