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“…3000–3600 cm −1 is attributed to the O–H bond of the coordinated water molecules and free water molecules. 39–42 The above-mentioned results indicate that the metal ions Zn 2+ successfully coordinate with BTC and/or PTA in all samples. MOF-DL2, MOF-DL3, MOF-DL4, and MOF-SL5 have distinctly different vibrational band shapes from MOF-SL1 in the range of 700–1200 cm −1 , which can be considered the fingerprint of PTA compounds.…”
In this study, we have successfully fabricated high-performance trimethylamine (TMA) sensor. Defect-engineering (DE) strategy in which two organic ligands, i.e., dicarboxylate and tricarboxylate coordinated with Zn2+ ions simultaneously is adopted...
“…3000–3600 cm −1 is attributed to the O–H bond of the coordinated water molecules and free water molecules. 39–42 The above-mentioned results indicate that the metal ions Zn 2+ successfully coordinate with BTC and/or PTA in all samples. MOF-DL2, MOF-DL3, MOF-DL4, and MOF-SL5 have distinctly different vibrational band shapes from MOF-SL1 in the range of 700–1200 cm −1 , which can be considered the fingerprint of PTA compounds.…”
In this study, we have successfully fabricated high-performance trimethylamine (TMA) sensor. Defect-engineering (DE) strategy in which two organic ligands, i.e., dicarboxylate and tricarboxylate coordinated with Zn2+ ions simultaneously is adopted...
“…The XRD patterns of ceph@MOF-5 also demonstrated very similar diffraction patterns, as compared to the patterns of the pristine MOF-5 and met@MOF-5. This indicates that the crystallinity of the MOF-5 was unaffected by the presence of the Ceph drug molecules [44]. This showed all the major and minor peaks of the pristine MOF-5 as shown in Figure 1.…”
The sustained and controlled delivery of antimicrobial drugs has been largely studied using nanomaterials, like metal organic frameworks (MOFs), and various polymers. However, not much attention has been given to combining MOFs and biodegradable polymers towards the potentially more sustained release of active pharmaceutical ingredients. Herein, we report a comparative study of two widely used antimicrobial drugs, cephalexin and metronidazole, from zinc-based MOF-5 incorporated into biodegradable polycaprolactone (PCL) and poly-lactic glycolic acid (PLGA) composites. Cephalexin and metronidazole were separately loaded into MOF-5 post-synthetically, followed by their integration into biodegradable PLGA and PCL composites. The pristine MOF-5 and the loaded MOFs were thoroughly characterised using Fourier-transformed infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and powder X-ray diffraction (PXRD). Ultraviolet-visible (UV-Vis) spectroscopy studies were carried out to assess the release of the drugs in PBS for up to 72 h, showing a cumulative release of 24.95 wt% and 27.84 wt% for cephalexin and metronidazole, respectively. The antibacterial properties of the pristine MOF, pure drugs, drug-loaded MOFs and the loaded composites were assessed against Gram-positive and Gram-negative bacterial strains, Staphylococcus aureus or Staphylococcus epidermidis and Escherichia coli or Acinetobacter baumanii, respectively. A cephalexin-loaded MOF-5 composite of PCL (PCL-ceph@MOF-5) showed the best efficiency for the controlled release of drugs to inhibit the growth of the bacteria compared to the other composites. This study demonstrates that the combination of MOFs with biodegradable polymers can provide an efficient platform for the sustained release of antimicrobial drugs and can be a promising tool to manage antimicrobial resistance (AMR).
“…While, the weight loss value between 400 and 535 °C was ≈53.97 wt.% for MOF‐5 (Figure S1b, Supporting Information), which were attributed to the removal of the adsorbed water and the decomposition process of the (H 2 BDC) ligands. [ 51 ] Comparably, the weight loss values were around 26.16, 24.70, and 23.63 wt.% for MOF@CP‐100 (Figure S1c, Supporting Information), MOF@CP‐150 (Figure S1d, Supporting Information), and MOF@CP‐250 (Figure S1e, Supporting Information), in which, their decomposition temperature were ≈350 °C. Accordingly, it can be roughly estimated that the amount of the loaded‐MOF‐5 was ≈42.52, 39.5, and 37.29 wt.% in MOF@CP‐100, MOF@CP‐150, and MOF@CP‐250, respectively.…”
The MOF‐5@clinoptilolite (MOF@CP) composites are successfully synthesized using polyvinylpyrrolidone (PVP) for adsorption separation of CO2/CH4, CO2/N2, and CH4/N2. The effects of the PVP amounts on the dispersity of MOF‐5 on CP random lamellas of the MOF@CPs are evaluated via various characterizations. Meanwhile, their single‐component gas adsorption isotherms, breakthrough experiments, and cycling test are measured. The results elucidate that the used PVP amount has a significant influence on the particle size and the uniformity of MOF‐5 dispersed on CP random lamellas. The MOF‐5‐loaded amount in MOF@CP is estimated to be up to 42.52 wt.%. Especially, the surface fractal evolutions indicated the surfaces of MOF@CP became from rough to smooth with the increase of PVP. The CO2/CH4, CO2/N2, and CH4/N2 selectivity factors of MOF@CP are higher than that of CP, displaying a better separation performance. Their cycling test revealed that MOF@CPs could be used repetitively, highlighting efficiency for CO2 and CH4 separation. Meanwhile, the MOF‐5@CP stability under moisture is preliminarily investigated, showing higher moisture resistance stability than MOF‐5. Additionally, the grand canonical Monte Carlo simulations demonstrated the adsorption separation mechanism of the prepared MOF@CPs.
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