A facile and effective procedure for the synthesis of new 1,3-thiazine-2-thione derivatives

Abstract

A four-component synthesis of 3,6-dihydro-2H-1,3-thiazine-2-thione derivatives from amines, carbon disulfide, arylglyoxals, and malononitrile in aqueous EtOH, at room temperature is reported.

Four-Component Reaction of α-naphthol, an Arylglyoxal, Aniline and a Dialkyl Acetylenedicarboxylate: A Michael Addition of Enamines to α,β-unsaturated γ-dicarbonyl Compounds

“…In continuation of our studies on one-pot multi-component reactions, [22][23][24] we report here a one-pot four-component reaction of aniline and a dialkyl acetylenedicarboxylate (to form enamines as Michael donors) and α-naphthol and an arylglyoxal (to form α,β-unsaturated γ-dicarbonyl compounds as Michael acceptors) without using a catalyst in ethanol at reflux conditions (Scheme 1).…”