A Extensively drug-resistant Pseudomonas putida bacteremia that was resolved spontaneously

Akbaş, Feray

doi:10.3855/jidc.11213

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…Infections by other Pseudomonas species with an environmental origin and biotechnological potential, as Pseudomonas putida [ 112 , 113 , 114 , 115 ], have also been reported, although their prevalence is much lower. Besides intrinsic resistance determinants [ 116 , 117 ], the acquisition of carbapenemases, as KPC-2 [ 113 ], constitutes an additional risk for the efficient treatment of infections by these pathogens.…”

Section: Pseudomonas Aeruginosamentioning

confidence: 99%

Coming from the Wild: Multidrug Resistant Opportunistic Pathogens Presenting a Primary, Not Human-Linked, Environmental Habitat

Sanz-García

Gil-Gil

Laborda

et al. 2021

IJMS

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The use and misuse of antibiotics have made antibiotic-resistant bacteria widespread nowadays, constituting one of the most relevant challenges for human health at present. Among these bacteria, opportunistic pathogens with an environmental, non-clinical, primary habitat stand as an increasing matter of concern at hospitals. These organisms usually present low susceptibility to antibiotics currently used for therapy. They are also proficient in acquiring increased resistance levels, a situation that limits the therapeutic options for treating the infections they cause. In this article, we analyse the most predominant opportunistic pathogens with an environmental origin, focusing on the mechanisms of antibiotic resistance they present. Further, we discuss the functions, beyond antibiotic resistance, that these determinants may have in the natural ecosystems that these bacteria usually colonize. Given the capacity of these organisms for colonizing different habitats, from clinical settings to natural environments, and for infecting different hosts, from plants to humans, deciphering their population structure, their mechanisms of resistance and the role that these mechanisms may play in natural ecosystems is of relevance for understanding the dissemination of antibiotic resistance under a One-Health point of view.

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Section: Pseudomonas Aeruginosamentioning

confidence: 99%

Coming from the Wild: Multidrug Resistant Opportunistic Pathogens Presenting a Primary, Not Human-Linked, Environmental Habitat

Sanz-García

Gil-Gil

Laborda

et al. 2021

IJMS

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“…The bacterial isolates were positive for oxidase, catalase, and growth at 42ºC, while the negative result for the indole test, methyl red test, methyl red -voges proskauer (MR-VP) test, gram stain, citrate utilization, and urease test. [26][27][28] The PCR product from the P.aeruginosa isolates was sequenced by DNA sequencer, and the sequence data compared using the BLAST program in NCBI, by which the PASS primers of 16S rDNA was aligned. The sequence analysis of these isolates showed strong similarities with the representative isolates that were retrieved from the NCBI database, and also determined the phylogenetic affiliation, based on nucleotide homology and phylogenetic analysis.…”

Section: Distribution Of Pseudomonas Spp According To Sexmentioning

confidence: 99%

“…However, there are numerous reports of wound and eye infections, bacteremia, urinary tract infection, central venous catheter infection, pneumonia, and soft tissue infections caused by P. putida. [4][5][6][7][8] P. luteola may cause infections of the bloodstream associated with pancreatitis, intravenous indwelling catheters, prosthetic valve endocarditic, foreign bodies, and coetaneous abscesses. Infrequently, non-bacteremia cases have been RESEARCH ARTICLE reported as post neurosurgical infections, fatal meningitis, appendicitis, or peritoneal dialysis catheters femur abscess, endophthalmitis, facial cellulite, leg ulcer in a patient with the sickle disease, peritonitis complicating, subphrenic abscess, and hand infection.…”

Section: Introductionmentioning

confidence: 99%

Identification of Clinical Pseudomonas spp. by VITEK 2 Compact System and Species-specific Polymerase Chain Reaction Assay for Identification of Pseudomonas aeruginosa

Said¹,

Hasan²,

Hamed³

2020

ijddt

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The objective of this study was to isolate, identify, and diagnose Pseudomonas spp. from different clinical sources in Baghdad, Iraq. VITEK 2 compact system identification gram-negative bacteria (ID gNB) cards were used to confirm the identification. Polymerase chain reaction (PCR) technique and sequencing were used for recognition of the 16S rDNA gene, by two pairs of primers, universal primers (930 bp fragments) for recognition of Pseudomonas spp., and Pseudomonas aeruginosa specific species (PASS) primers (956 bp fragments) for differentiation of P. aeruginosa from other species. Amplified PCR products of PASS primers were sent for DNA Sanger sequencing to Macrogen Company, Seoul, Korea; data were compared with the database using the Basic Local Alignment Search Tool (BLAST). Ninety-two Pseudomonas spp., including 86 isolates of P. aeruginosa and 1, 2, 3 isolates of Pseudomonas luteola, Pseudomonas putida, and Pseudomonas fluorescens, respectively, were obtained using VITEK 2 compact system ID gNB cards with a percentage of identification ranging from 91 to 99%. Gene amplification and sequencing results confirm identification ranging from 99 to 100%. After sequencing analysis, eleventh of the P. aeruginosa isolates had been submitted in GenBank National Centre for Biotechnology Information (NCBI) under accession numbers MN630696–MN630707. It was observed that phenotypic tests supported by PCR techniques have enabled to conduct a detailed characterization of Pseudomonas bacteria isolates.

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“…Although this microbial agent causes infections in cancer and immunosuppressed patients and is less virulent than Pseudomonas aeruginosa , fatal diseases have been reported. [4,5]…”

Section: Introductionmentioning

confidence: 99%

“…Although this microbial agent causes infections in cancer and immunosuppressed patients and is less virulent than Pseudomonas aeruginosa, fatal diseases have been reported. [4,5] P. putida infections used to be known to have a good prognosis. However, recent studies reported a high mortality rate (40%), particularly in patients with comorbid conditions, [5,6] attracting the attention of clinicians.…”

Section: Introductionmentioning

confidence: 99%

Clinical features, risk factors, and antimicrobial resistance of pseudomonas putida isolates

Baykal¹,

Çelik

Ülger³

et al. 2022

Medicine

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Pseudomonas putida rarely results in infection, primarily in patients undergoing invasive procedures or immunocompromised hosts. We aimed to investigate the characteristics of Pseudomonas putida infections. This is a retrospectively designed cross-sectional observational study. We retrospectively scanned the data from our hospital for the 10 years before February 15, 2022. The patients with Pseudomonas putida growth in the microbiological cultures and with antibiotic susceptibility tests were included in the study. We recorded culture isolates types, age, gender, comorbidities, immunosuppressive factors, symptoms, invasive medical procedures, length of hospital stay, and radiological findings. The mean age of the patients was 66.2 ± 14.5 years, and the male patients predominated (76.3%, n = 58/76). There was growth in bronchial lavage in 33 patients, sputum in 28, pleural effusion fluid in 12, and tracheal aspirate in 3 patients. The rate of antibiotic-resistant strains was 56.6% (n = 43). All strains were sensitive to colistin (100%), and carbapenem, amikacin, and gentamicin sensitivity rates were high. We observed that the risk of antibiotic resistance increased 4.29 times in the patients in the intensive care unit (Cl:1.27–14.47, P = .01). The patients with Diabetes Mellitus had a higher risk (OR 4.33, Cl:1.11–16.77, P = .03), and in cancer cases, the risk was 3.31 times higher (Cl:1.06–10.32, P = .03). The risk of Pseudomonas putida infection should be considered, particularly in patients with comorbid disorders causing immunosuppression, including Diabetes Mellitus and Cancer.

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A Extensively drug-resistant Pseudomonas putida bacteremia that was resolved spontaneously

Cited by 6 publications

References 24 publications

Coming from the Wild: Multidrug Resistant Opportunistic Pathogens Presenting a Primary, Not Human-Linked, Environmental Habitat

Coming from the Wild: Multidrug Resistant Opportunistic Pathogens Presenting a Primary, Not Human-Linked, Environmental Habitat

Identification of Clinical Pseudomonas spp. by VITEK 2 Compact System and Species-specific Polymerase Chain Reaction Assay for Identification of Pseudomonas aeruginosa

Clinical features, risk factors, and antimicrobial resistance of pseudomonas putida isolates

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