A expressão da IL-17A por melanócitos neoplásicos e seu possível envolvimento no escape da resposta imune antitumoral

Nunes, Larissa Mesquita; Sobrinho, Hermínio Maurício da Rocha; Silva, Camila de Magalhães Nardelli; Modesto, Déborah Capel; Marinho, Larissa Cardoso; Wastowski, Isabela Jubé

doi:10.18224/est.v43i1.5200

EST

2016

DOI: 10.18224/est.v43i1.5200

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A expressão da IL-17A por melanócitos neoplásicos e seu possível envolvimento no escape da resposta imune antitumoral

Larissa Mesquita Nunes

Hermínio Maurício da Rocha Sobrinho

Camila de Magalhães Nardelli Silva

et al.

Abstract: Resumo: A expressão da citocina pró-inflamatória interleucina 17 (IL-17), produzida especialmente por células Th17 por melanócitos neoplásicos pode contribuir para o crescimento das células tumorais e a angiogênese, colaborando para o escape da resposta imune tumoral. Objetivo: avaliar a expressão da citocina IL-17 em amostras histológicas de 47 pacientes com diagnóstico de melanoma atendidos em um Hospital de Oncologia de Goiânia-GO. Método: as amostras histológicas dos pacientes diagn… Show more

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Relationship between Th17 immune response and cancer

Marques¹,

Brito²,

Silva³

et al. 2021

WJCO

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Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades. Cancer has a close relationship with the immune system and, although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity, studies have emphasized their roles in cancer pathogenesis. The Th17 immune response profile is involved in several types of cancer including urogenital, respiratory, gastrointestinal, and skin cancers. This type of immune response exerts pro and antitumor functions through several mechanisms, depending on the context of each tumor, including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment. Among other factors, the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential, which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells. Interleukin (IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment, which allow Th17 cells to prevail in tumors. Moreover, the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers, being associated with variable clinical outcomes. The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.

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Relationship between Th17 immune response and cancer

Marques¹,

Brito²,

Silva³

et al. 2021

WJCO

View full text Add to dashboard Cite

show abstract

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A expressão da IL-17A por melanócitos neoplásicos e seu possível envolvimento no escape da resposta imune antitumoral

Cited by 1 publication

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Relationship between Th17 immune response and cancer

Relationship between Th17 immune response and cancer

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