A Europium MOF-based turn-off fluorescent sensor for tryptophan detection in human serum, urine and lake water

Liu, Qirui; Liu, Bing; Qiu, Miao-Miao; Miao, Wei-Ni; Xu, Ling

doi:10.1016/j.jssc.2022.123138

Cited by 21 publications

(5 citation statements)

References 38 publications

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“…Therefore, more effort should be made to seek materials for the quick, convenient, accurate, and real-time detection of UA and 1-HP in the human body. Compared with these traditional methods, luminescent sensors based on luminescent metal–organic frameworks (LMOFs) have been widely considered because of their simple operation, excellent selectivity, and fast response for detecting target substances. − Specifically, lanthanide metal–organic frameworks (Ln-MOFs) have received considerable attention because of their fascinating luminescence properties, such as strong emission peaks, long lifetimes, and high luminescence efficiency. − In recent years, Ln-MOFs have been extensively applied as potential luminescent sensors for various ions, − organic molecules, − temperature, − amino acids, − antibiotics, − and some biomarkers. − However, it is found that luminescent sensors for recognizing UA and 1-HP in human urine based on Ln-MOFs are rarely reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Notably Stable Bifunctional Europium-Centered Metal–Organic Framework for Instant Sensing of Uric Acid and 1-Hydroxypyrene in Human Urine

Zhang

et al. 2023

Inorg. Chem.

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A new Eu-centered metal−organic framework, [(CH 3 ) 2 NH 2 ][Eu(cdip)(H 2 O)] (compound 1), was fabricated by the reaction of Eu(NO 3 ) 3 •6H 2 O and a high-symmetry ligand, 5,5′-carbonyldiisophthalic acid (H 4 cdip). Interestingly, compound 1 exhibits extraordinary stability, including air, thermal, and chemical stabilities, in an aqueous solution with a broad pH range of 1−14, which is rarely seen in the field of metal−organic framework materials. Notably, compound 1 is proved to be an exceptional prospective luminescent sensor for recognizing 1hydroxypyrene and uric acid both in DMF/H 2 O solution and human urine with a fast response (1-HP: 10 s; UA: 80 s), high quenching efficiency K sv (7.01 × 10 4 M −1 for 1-HP and 5.46 × 10 4 M −1 for UA in DMF/H 2 O solution; 2.10 × 10 4 M −1 for 1-HP and 3.43 × 10 4 M −1 for UA in human urine), low limit of detection (1.61 μM for 1-HP and 0.54 μM for UA in DMF/H 2 O solution; 0.71 μM for 1-HP and 0.58 μM for UA in human urine), and remarkable anti-interference ability based on luminescence-quenching effects observable by the naked eye. This work provides a new strategy for the exploration of potential luminescent sensors based on Ln-MOFs for 1-HP, UA, or other biomarkers in biomedical and biological fields.

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Section: Introductionmentioning

confidence: 99%

Notably Stable Bifunctional Europium-Centered Metal–Organic Framework for Instant Sensing of Uric Acid and 1-Hydroxypyrene in Human Urine

Zhang

et al. 2023

Inorg. Chem.

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“…Compared to those methods, fluorescence with the features of rapid response, easy operation, and high sensitivity is as a simple and convenient tool for monitoring AA, attracting much attention. The fluorescence materials cover nanomaterials, [8][9][10] enzyme, [11] metal-organic frameworks (MOFs), [12][13][14][15] and etc. MOFs or coordination polymers are an important material source of fluorescence sensors.…”

Section: Introductionmentioning

confidence: 99%

A Water‐Stable Europium Metal‐Organic Framework as a Turn‐Off Fluorescence Sensor for Ascorbic Acid Detection in Human Serum

Yin,

Liu,

Zheng

et al. 2024

Eur J Inorg Chem

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Ascorbic acid (AA) is a biomarker of some nervous system diseases, whose detection is of significance in many fields. The hydrothermal reaction of naphthalene‐2,6‐dicarboxylic acid (H2NDBC) with Eu3+ produced a europium MOF, Eu‐NDBC. Eu‐NDBC emits the combined emissions from the intraligand charge transfer (ILCT) of NDBC2‒ ligand and 5D0→7Fj (j = 1‐4) transfers of Eu(III). The factors of MOF dosage, pH and fluorescence response time are optimized as 0.6 mg, 7.35, and 5 min respectively. The sensitivity test shows a linear fitting equation of I0/I = 0.00239·CAA+1.03774 (CAA = AA concentration), with its limit of detection calculated as 4.53 µM in a wide linear range of 0‐900 µM. The linear fitting of Stern‐Volmer equation gives KSV = 2.46×103 M‒1 and Kq = 4.96×106 M‒1∙S‒1, suggesting Eu‐NDBC sensing AA is a dynamic fluorescence quenching process. Nine control amino acids can’t affect Eu‐NDBC sensing AA and the emission intensity stay stable in five fluorescence quenching‐recovery cycles. The returned CAA closed to the set CAA and the recoveries around 100% support the accurate AA detection by Eu‐NDBC in human serum. Totally, Eu‐NDBC can be regarded as a quantitative turn‐off fluorescence sensor to AA with high sensitivity and selectivity, rapid response and durability.

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“…Trp participates in the renewal of plasma protein in animals and enables riboflavin to work well . Besides, Trp is also conducive to the synthesis of niacin and heme, significantly increasing the antibodies in the fetus of pregnant animals. , The deficiency of Trp in livestock and poultry can lead to serious consequences on their bodies, such as retarded growth, weight loss, decreased fat accumulation, and the atrophy of the testicles of breeding animals. , Therefore, effective and specific detection of Trp is of profound significance for the diagnosis and prevention of diseases and dietary nutrition fields.…”

Section: Introductionmentioning

confidence: 99%

Exploration of the Capacity of a Superstable Eu-MOF for Visualized Identification of 1-HP and Trp in Fresh Human Urine

Liu,

Xu,

Zhang

et al. 2024

Crystal Growth & Design

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1-Hydroxypyrene (1-HP) is known as the end product of polycyclic aromatic hydrocarbons (PAHs). Monitoring the content of 1-hydroxypyrene in human urine or serum can help measure the degree of polycyclic aromatic hydrocarbon poisoning in the human body. Tryptophan (Trp), one of the eight essential amino acids, plays a vital role in human growth and development. Therefore, exploration of a promising sensor for instant and accurate recognition of 1-HP and Trp has a profound influence on human health. Herein, a threedimensional (3D) europium-centered metal−organic framework ([Eu-(H 2 O) 5 ] 0.33 [Eu(obdb)]•2DMF, Eu-MOF) with amazing air stability, acid−base stability, and thermal stability was constructed through the coordination interaction between Eu(III) ions and a V-typed semirigid ligand with two isophthalate groups (H 4 obdb, 4′,4‴-oxybis([1,1′biphenyl]-3,5-dicarboxylic acid)) under a solvothermal condition. As expected, Eu-MOF can recognize 1-HP and Trp in binary solutions of DMF-H 2 O based on a significantly luminescent turn-off effect with high quenching efficiencies (99.2% for 1-HP and 93.8% for Trp), charming quenching constants (2.15 × 10 4 M −1 for 1-HP and 4.88 × 10 4 M −1 for Trp), low limit of detection (1.10 μM for 1-HP and 0.73 μM for Trp), and satisfactory antijamming capability. In addition, for detection of 1-HP or Trp, the color change of Eu-MOF from red to blue is visible to the naked eye as the concentration of 1-HP or Trp increases under a 365 nm UV lamp. Moreover, except in DMF-H 2 O solutions, the sensing capacities of Eu-MOF toward 1-HP and Trp are proven to be comparable in HEPES buffer solution and real samples.

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A Europium MOF-based turn-off fluorescent sensor for tryptophan detection in human serum, urine and lake water

Cited by 21 publications

References 38 publications

Notably Stable Bifunctional Europium-Centered Metal–Organic Framework for Instant Sensing of Uric Acid and 1-Hydroxypyrene in Human Urine

Notably Stable Bifunctional Europium-Centered Metal–Organic Framework for Instant Sensing of Uric Acid and 1-Hydroxypyrene in Human Urine

A Water‐Stable Europium Metal‐Organic Framework as a Turn‐Off Fluorescence Sensor for Ascorbic Acid Detection in Human Serum

Exploration of the Capacity of a Superstable Eu-MOF for Visualized Identification of 1-HP and Trp in Fresh Human Urine

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