A European Multicenter Randomized Noninferiority Trial Comparing 180 W GreenLight XPS Laser Vaporization and Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Obstruction: 12-Month Results of the GOLIATH Study

Bachmann, Alexander; Tubaro, Andrea; Barber, Neil; d’Ancona, Frank; Muir, Gordon; Witzsch, U.; Grimm, Marc‐Oliver; Benejam, Joan; Stolzenburg, Jens‐Uwe; Riddick, Antony C. P.; Pahernik, Sascha; Roelink, Herman; Ameye, Filip; Saussine, C.; Bruyère, F.; Loidl, Wolfgang; Larner, Tim; Gogoi, Nirjan-Kumar; Hindley, Richard G.; Muschter, R.; Thorpe, Andrew; Shrotri, Nitin; Graham, Stuart; Hamann, Moritz; Miller, Kurt; Schostak, Martin; Capitán, Carlos; Knispel, Helmut H.; Thomas, James A.

doi:10.1016/j.juro.2014.09.001

Cited by 120 publications

(86 citation statements)

References 19 publications

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“…Eighteen RCTs with a total 2433 participants (mean age 67.53 years) finally met full inclusion criteria for current metaanalysis. [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] Figure 1 showed the flowchart of literature searches and Table 1 provided characteristics of the included trials. These studies were conducted in 7 different countries located in Europe, North America, and Asia.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…There were 11 studies [35,37,[39][40][41][42]45,47,[49][50][51] including 24 direct comparisons of post-TURP IIEF-5 score with pre-TURP one. As shown in Fig.…”

Section: Directly Comparing Post With Pretreatment Efmentioning

confidence: 99%

“…Laser technologies are widely used in prostate surgery. The present study covered HoLEP, HoLRP, PVP, and Thulium laser approaches, of which there were 4, [35,36,42,43] 1, [38] 4, [38][39][40]51] and 2 [45,49] trials containing 9, 3, 9, and 3 direct post versus pretreatment comparisons, respectively. The pooled outcomes of all 4 kinds of laser technologies on EF were displayed in Fig.…”

Section: Directly Comparing Post With Pretreatment Efmentioning

confidence: 99%

“…Group of decreased baseline IIEF-5 score covered all 9 surgical approaches with 15 articles. [36][37][38][39][40][41][43][44][45][46][47][48][50][51][52] As shown in Fig. 5 (B-E), patients who underwent TURP (P = 0.188, SMD = 0.06, 95% CI À0.03 to 0.15, I 2 = 32.7%, P = 0.084), PKRP (P = 0.545, SMD = 0.04, 95% CI À0.09 to 0.16, I 2 = 59.9%, P = 0.000), HoLRP (P = 0.682, SMD = 0.05, 95% CI À0.17 to 0.26, I 2 = 0.0%, P = 0.956), Thulium laser (P = 0.093, SMD = 0.23, 95% CI À0.04 to 0.51, I 2 = 0.0%, P = 0.709), OP (P = 0.220, SMD = 0.19, 95% CI À0.11 to 0.49, I 2 = 76.3%, P = 0.000), and LSP (P = 0.831, SMD = 0.02, 95% CI À0.18 to 0.23, I 2 = 0.0%, P = 0.999) had no effect on EF, whereas patients who underwent HoLEP (P = 0.006, SMD = 0.39, 95% CI 0.11-0.66, I 2 = 60.6%, P = 0.038) and PKEP (P = 0.000, SMD = 0.29, 95% CI 0.19-0.39, I 2 = 0.0%, P = 0.515) had an increased postoperative IIEF-5 score.…”

Section: Subgroup Analysismentioning

confidence: 99%

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165 The Impact of Surgical Treatments for Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia on Male Erectile Function: A Systematic Review and Network Meta-Analysis

Chen

Guo

et al. 2017

The Journal of Sexual Medicine

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Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…There were 11 studies [35,37,[39][40][41][42]45,47,[49][50][51] including 24 direct comparisons of post-TURP IIEF-5 score with pre-TURP one. As shown in Fig.…”

Section: Directly Comparing Post With Pretreatment Efmentioning

confidence: 99%

Section: Directly Comparing Post With Pretreatment Efmentioning

confidence: 99%

Section: Subgroup Analysismentioning

confidence: 99%

See 2 more Smart Citations

165 The Impact of Surgical Treatments for Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia on Male Erectile Function: A Systematic Review and Network Meta-Analysis

Chen

Guo

et al. 2017

The Journal of Sexual Medicine

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“…The former is referred to here as photoselective vaporisation of the prostate (PVP); PVP using a 180-watt green-light laser with saline irrigation has shown no inferiority to TURP [18]. …”

Section: Introductionmentioning

confidence: 99%

Measurement of Procedure-Specific Irrigation-Fluid Absorption in Transurethral Therapy of Lower Urinary Tract Syndrome, Using Ethanolic Saline and Breath Alcometry

Porsch

Mittelstädt²,

Wendler³

et al. 2016

Urol Int

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Introduction: Transurethral resection risks excessive absorption of irrigating fluid with potentially severe or life-threatening consequences. We determined the amount of absorbed saline irrigation fluid during photoselective vaporisation of the prostate (PVP) and bipolar transurethral resection of the prostate (bTURP). Patients and Methods: Patients at our institution treated by one of these methods were monitored by the alcometric method: ethanol is added to the irrigation fluid and blood alcohol is measured with a breathalyser. Various possible correlations were investigated. Results: Data from 71 patients (36 PVP, 35 bTURP) were analysed. Detection of any absorption was more frequent under bTURP (71% of patients) than under PVP (39%; p = 0.006). Absorption in the volume range 500-1,000 ml was conspicuously more frequent in the bTURP procedure than in PVP. Conclusions: Presence of absorption was more frequent under bTURP than under PVP. However, high-volume absorption was more frequent during bTURP than in PVP.

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Prostatic urethral lift for subjects in urinary retention (PULSAR): 12‐Month results of a prospective controlled trial compared with real‐world outcomes

Rochester,

Doherty,

Page

et al. 2023

BJUI Compass

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ObjectiveTo examine the safety and efficacy of prostatic urethral lift (PUL) in acute urinary retention (AUR) patients within a controlled (PULSAR) and real‐world setting (Real‐World Retrospective study).Materials and methodsPULSAR was a 12‐month prospective study of PUL in AUR patients (n = 51) performed at six centres in the United Kingdom; enrolled BPH patients aged ≥50 years, with prostate volume of ≤100 cc. AUR was defined as being catheter dependent with at least one prior failed trial without catheter (TWOC) while on an alpha‐blocker. RWR consisted of 3226 consecutive PUL patients across 22 international sites treated between July 2017 and March 2020; 469 of whom were in urinary retention (RWRr), that is, catheter‐dependent at the time of their procedure. Symptom response, uroflow and catheter independence rates were compared between PULSAR and RWRr subjects. A logistical regression model was constructed to evaluate patient baseline and dynamic factors predicting success after the procedure.ResultsSeventy‐three percent of PULSAR subjects were catheter independent and free from surgical reintervention at 12 months post‐PUL. Success was associated with higher voiding efficiency during the perioperative period. Slightly higher catheter‐independent rates (80%) were seen in RWRr patients; variables that influenced success included age <70 years, lower baseline prostate‐specific antigen (PSA), lower baseline post‐void residual (PVR) and shorter pre‐procedural catheter duration. Logistic regression of the combined PULSAR and RWRr retention groups revealed that procedural age <70 years and higher bladder voiding efficiency (BVE) were associated with success.ConclusionsLower baseline PSA and PVR, younger age and shorter pre‐procedure catheter durations drove successful outcomes in AUR patients undergoing PUL. Post‐PUL voiding efficiencies may help ascertain long‐term response to treatment.

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A European Multicenter Randomized Noninferiority Trial Comparing 180 W GreenLight XPS Laser Vaporization and Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Obstruction: 12-Month Results of the GOLIATH Study

Abstract: Followup at 1 year demonstrated that photoselective vaporization of the prostate produced efficacy outcomes similar to those of transurethral resection of the prostate. The complication-free rates and overall reintervention rates were comparable between the treatment groups.

Cited by 120 publications

References 19 publications

165 The Impact of Surgical Treatments for Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia on Male Erectile Function: A Systematic Review and Network Meta-Analysis

165 The Impact of Surgical Treatments for Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia on Male Erectile Function: A Systematic Review and Network Meta-Analysis

Measurement of Procedure-Specific Irrigation-Fluid Absorption in Transurethral Therapy of Lower Urinary Tract Syndrome, Using Ethanolic Saline and Breath Alcometry

Prostatic urethral lift for subjects in urinary retention (PULSAR): 12‐Month results of a prospective controlled trial compared with real‐world outcomes

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