A eudesmane acid from Montanoa speciosa

Seaman, Fred C.; Bencsath, Aladar

doi:10.1016/s0031-9422(00)80781-5

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…Its structure was definitively determined to be 5aH-2b,4b-epoxy-3a-hydroxyguaia-1(10),11(13)-dien-6a,12olide by 1D-, and 2D-NMR spectroscopy and EI-MS data, applying the same strategy as described for compound 1 (see Tables 1 and 2 for 1 H-, 13 C-NMR data). Compound 4 was identified as 1b,6a-dihydroxycostic acid on the basis of extensive 1D-, 2D-NMR and EI-MS studies (see Tables 1 and 2 for 1 H-, 13 C-NMR data) as well as by comparison of the obtained data with literature values of costic acid derivatives [7], [8]. The spectral (NMR, MS, UV) and physical (melting point, optical rotation) data of the known compounds 2, 3, 5, 7 and 8 (hispidulin) were in complete accordance with those reported in the literature [9], [10], [11], [12], [13], [14], [15].…”

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confidence: 99%

New Cytotoxic Sesquiterpene Lactones fromWarionia saharae

2003

Planta med

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Cytotoxicity-guided fractionation of the methanol soluble part of the dichloromethane extract of the leaves of Warionia saharae led to the isolation of the two new guaianolide-type sesquiterpene lactones, 5 alpha H-3 beta,4 beta-epoxy-14-oxo-guaia-1(10),11(13)-dien-6 alpha,12-olide (1), 5 alpha H-2 beta,4 beta-epoxy-3 alpha-hydroxy-guaia-1(10),11(13)-dien-6 alpha,12-olide (6), and the new eudesmane type sesquiterpene 1 beta,6 alpha-dihydroxycostic acid ( 4). In addition, the known sesquiterpene lactones 5 alpha H-2 beta-hydroxyguaia-3(4),10(14),11(13)-trien-6 alpha,12-olide (2), reynosin (3), 5 alpha H-1 alpha,10 alpha:3 alpha,4 alpha-diepoxyguaia-11(13)-en-6 alpha,12-olide (5), and dehydroleucodin (7) were isolated together with the known flavone hispidulin. Cytotoxicity testing of the sesquiterpene lactones against the KB cancer cell line (ATCC CCL17) revealed IC50 values of 3.5 (1), 2.6 ( 2), 2.7 ( 3), 4.3 ( 5), 3.6 ( 6), and 1.3 (7) microg/mL. Compound 4 was not active up to 20 microg/mL.

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