The bioeconomy utilizes living organisms and processes them to produce of food, fuel, fine chemicals, and other substances. Macroalgae are promising feedstocks for chemical products while sequestering carbon. There is a need for methodologies for economic and policy analysis of novel bioeconomy technologies, taking into account environmental side effects and physical and economic uncertainties.The aims of the feasibility study BARD Project No. US-4986-17 F were twofold: First, to develop a methodology to assess the economic feasibility of biological feedstock cultivation and processing into co-products. The methodology addressed various parameters, associated with the new technology, and assessed the performance of the integrated supply chain that includes feedstock and processing to produce sugars and proteins. Second, to apply this system to assess the profitability of producing commodity biochemicals from macroalgae under various assumptions about growth rates of the feedstock, prices and costs, conversion factors in the biorefinery and technological learning.Following the original objectives of this study, we developed a novel methodology to assess the performance of the integrated two-stage supply chainfeedstock farming and processing into multiple outputs. The modeling framework clarifies that learning in multi-stage supply chain creates a positive externality of co-outputs. Moreover, if learning rate is faster than cost increase, then output grows faster than prices. Next, we demonstrated the application of this non-linear dynamic model on macroalgae (seaweed) farming and processing in the biorefinery into crude proteins and polysaccharide (carrageenan). Our computational experiments identified the set of conditions in terms of costs, prices of outputs, shares of co-outputs in the biorefinery, as well as technological efficiency and R&D efforts that make production of biochemicals from macroalage worthwhile. The results indicate that for average prices of proteins and carrageenan, and for average costs of investment in cultivation farm and the biorefinery, macro algae utilization is cost-efficient. However, profitability of this supply chain is fragile due to high volatility of outputs' prices, as well as wide range of feedstock growth rate and chemical composition. We found that the main constrain for commercialization, is the first stage of the supply chain, namely macroalgae marine cultivation.The follow up study is planned to investigate the hypothesis that macroalgae derived commodity biochemical could provide a novel, sustainable and economic supply chain for the low-carbon food industry. The big scale macroalgae cultivation involves direct and external effects on marine environment, carbon absorption, potable water, land use and employment. Further analysis on macroalgae external costs and benefits, as well as social welfare analysis, is required for an accurate policy intervention. Accordingly, we will identify policy parameters, including pricing of greenhouse gas sequestration and other externali...