A dynamic nano-coordination protein hydrogel for photothermal treatment and repair of infected skin injury

Yin, Wang; Wang, Qiang; Zhang, Jinyi; Xu, Chunxiang; Wang, Yunlong; Jiang, Zhenhuan; Wang, Miao; Pan, Guoqing

doi:10.1039/d2tb01146h

Cited by 21 publications

(17 citation statements)

References 27 publications

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“…After that, the HAP-Ag/PDA was cross-linked with 4-arm PEG-SH to form a hydrogel through a double-cross-linking system. First, the silver ions on HAP-Ag surface react with the sulfhydryl groups of 4-arm PEG-SH to form Ag–S dynamic coordination bonds. , Second, free quinone groups on HAP-Ag can also react with the sulfhydryl groups of 4-arm PEG-SH, which further enhances the mechanical properties of the hydrogel. Hence, DA modification enables HAP-Ag to be well distributed in the hydrogel network (Figure S1) and provides cross-linking sites for enhanced mechanical support.…”

Section: Resultsmentioning

confidence: 99%

High-Strength Injectable Hydrogel into Perivascular Interstitial Space Enhances Arterial Adventitial Stress

Zhu

Zhang

et al. 2023

Langmuir

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Injectable hydrogels with strong mechanical properties have significant potential for biomedical applications, including the development of electronic skin, intelligent medical robots, as well as tissue engineering. In this study, we report on an injectable hydrogel with notable tensile strength and adhesion properties, achieved through cross-linking thiol-terminated four-arm poly (ethylene glycol) using silver-doped nano-hydroxyapatite, modified with dopamine. Subsequently, the hydrogel was injected in vivo through the perivascular interstitial space of rats. The hydrogel wrapped around the damaged abdominal aortic adventitia, which greatly increases the stress strength of the arterial adventitia. We found that the hydrogel was characterized by excellent biocompatibility, and it induced little immune response over a span of 21 days post-implantation. This simple and minimally invasive vascular protection strategy appears promising for the treatment of vascular diseases, such as abdominal aortic aneurysm (AAA).

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Section: Resultsmentioning

confidence: 99%

High-Strength Injectable Hydrogel into Perivascular Interstitial Space Enhances Arterial Adventitial Stress

Zhu

Zhang

et al. 2023

Langmuir

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“…The components of biofilms are complex. Bacteria are shielded by the extracellular matrix, which invalidates the host defense system and prevents antibiotics from contacting the encapsulated bacteria. − In addition, it is easy for bacteria in the biofilm to mutate, accelerating the development of bacterial resistance . Therefore, it is paramount but challenging to prevent the formation of biofilms and kill mature biofilms that have been formed.…”

Section: Resultsmentioning

confidence: 99%

Nonfouling and Antibacterial Zwitterionic Contact Lenses Loaded with Heme-Mimetic Gallium Porphyrin for Treating Keratitis

Zhang

et al. 2022

Langmuir

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Antifouling and antibacterial are two critical challenges in the development of contact lenses (CLs). Herein, we presented nonfouling and antibacterial bifunctionalized CLs by encapsulating cationic heme-mimetic gallium porphyrin (Ga-CHP) into zwitterionic-elastomeric-networked (ZEN) hydrogel. Results proved that the ZEN hydrogel showed excellent abilities to resist non-specific protein adsorption, bacterial adhesion, and biofilm formation. Moreover, Ga-CHP could be sustainably released and kill >99.9% planktonic bacteria and >99.9% mature biofilms. In vivo, the symptoms of bacterial keratitis in mice were significantly alleviated after wearing the CLs for 7 days via ironblocking and photodynamic synergistic antibacterial therapy with the help of natural sunlight. This study highlights the nonfouling and antibacterial superiority of the Ga-CHP-functional zwitterionic CLs and proposes a portable yet efficient non-antibiotic keratitis treatment strategy.

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“…Therefore, PTT may be an effective way to kill bacteria and even drug-resistant strains without inducing drug resistance. Pan et al reported a dynamic photothermal hydrogel that enabled rapid photothermal sterilization to accelerate infected skin healing …”

Section: Results and Discussionmentioning

confidence: 99%

“…Pan et al reported a dynamic photothermal hydrogel that enabled rapid photothermal sterilization to accelerate infected skin healing. 46 Herein, we built a subcutaneous abscess model by infecting BALB/c mice with drug-resistant S. aureus (Figure 7A). GNR-DPArPEGMA was injected into the abscess site and imaged by a thermal infrared camera under 808 nm NIR laser irradiation for 3 min.…”

Section: Antibiofilm Activitymentioning

confidence: 99%

Au Nanorods Coated with pH-Responsive Polymers for Photothermal Therapy Against Multidrug-Resistant Bacteria

Luo

Zhu

Qian

et al. 2022

ACS Appl. Nano Mater.

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Overuse of antibiotics has led to an increased threat of drug-resistant pathogens and sustained chronic infections, suggesting an urgent need for effective strategies against drugresistant bacterial infections. Herein, we developed au gold nanorods coated with pH-responsive polymers (GNR-DPArPEG-MA) for photothermal therapy against multidrug-resistant bacteria. The size and zeta potential of GNR-DPArPEGMA was 78 nm and −37.96 mV, respectively. In subacidic conditions, the nanocomposite surface was positively (14.18 mV) charged, leading to better bacterial adhesion and antibacterial efficiency. The nanocomposites showed augmented in vitro photothermal efficiency up to 70 °C under 808 nm irradiation for 3 min, which further demonstrated an enhanced photothermal bacteria-killing efficiency. The in vivo assays showed that GNR-DPArPEGMA irradiated with near-infrared radiation could treat a drug-resistant Staphylococcus aureus-caused subcutaneous abscess and drug-resistant Pseudomonas aeruginosa-caused pneumonia while reducing the number of bacteria and attenuating inflammation in the infected sites. These results indicate that the nanocomposites could be used as a potential photothermal agent to combat drug-resistant bacterial infections in the future.

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A dynamic nano-coordination protein hydrogel for photothermal treatment and repair of infected skin injury

Abstract: In this work, a dynamic photothermal hydrogel based on copper disulfide nanoparticle and thiolated gelatin was reported. The resultant hydrogel enabled rapid photothermal sterilization and the sterilization rate could reach...

Cited by 21 publications

References 27 publications

High-Strength Injectable Hydrogel into Perivascular Interstitial Space Enhances Arterial Adventitial Stress

High-Strength Injectable Hydrogel into Perivascular Interstitial Space Enhances Arterial Adventitial Stress

Nonfouling and Antibacterial Zwitterionic Contact Lenses Loaded with Heme-Mimetic Gallium Porphyrin for Treating Keratitis

Au Nanorods Coated with pH-Responsive Polymers for Photothermal Therapy Against Multidrug-Resistant Bacteria

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