“…As they represent a convenient compromise between prediction capabilities and simplicity, biochemical mechanistic models are the most commonly applied models (Darvehei et al, 2018;Shoener et al, 2019). Nevertheless, dedicated models have also been developed to consider other relevant factors, such as fluid heterogeneity in PBRs (e.g., via computational fluid dynamics (Ranganathan et al, 2022)), outdoors solar irradiance and light distribution throughout the culture (Acién Fernández et al, 1997;Béchet et al, 2013), or temperature prediction in the reactors (e.g., heat transfer modelling (Todisco et al, 2022)). Although none of these approaches has been applied for PPB systems, this technology could clearly benefit from them.…”