A durable, stretchable, and disposable electrochemical biosensor on three-dimensional micro-patterned stretchable substrate

Kim, Bo‐Yeong; Lee, Han‐Byeol; Lee, Nae‐Eung

doi:10.1016/j.snb.2018.12.045

Cited by 39 publications

(28 citation statements)

References 45 publications

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“…Although they are always present at relatively low concentrations in physiological fluids, they are of great interest for monitoring the chronic wound healing process as well as future diagnosis or management of diseases such as wound healing, Parkinson's disease, and depression. As an example, a stretchable electrochemical immunosensor was used to detect the protein of the TNF-α antibody to monitor wound healing (Figure 8a) [103]. TNF-α was immobilized on the working electrode and detected using a voltammetric technique of differential pulse voltammetry method.…”

Section: Biomolecules Monitoringmentioning

confidence: 99%

Wearable Biosensors for Non-Invasive Sweat Diagnostics

2021

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Recent advances in microfluidics, microelectronics, and electrochemical sensing methods have steered the way for the development of novel and potential wearable biosensors for healthcare monitoring. Wearable bioelectronics has received tremendous attention worldwide due to its great a potential for predictive medical modeling and allowing for personalized point-of-care-testing (POCT). They possess many appealing characteristics, for example, lightweight, flexibility, good stretchability, conformability, and low cost. These characteristics make wearable bioelectronics a promising platform for personalized devices. In this paper, we review recent progress in flexible and wearable sensors for non-invasive biomonitoring using sweat as the bio-fluid. Real-time and molecular-level monitoring of personal health states can be achieved with sweat-based or perspiration-based wearable biosensors. The suitability of sweat and its potential in healthcare monitoring, sweat extraction, and the challenges encountered in sweat-based analysis are summarized. The paper also discusses challenges that still hinder the full-fledged development of sweat-based wearables and presents the areas of future research.

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Section: Biomolecules Monitoringmentioning

confidence: 99%

Wearable Biosensors for Non-Invasive Sweat Diagnostics

2021

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“…As an early example, a stretchable electrochemical immunosensor was reported in 2018 ( Figure a). [ 185 ] Probe proteins (TNF‐ α antibody) were immobilized on the working electrode for selective detection of TNF‐ α using the DPV method (Figure 15a‐left). In the absence of TNF‐ α , the faradic currents recorded at the redox potentials were from the redox probe (ferricyanide).…”

Section: Soft Wearable Healthcare Devicesmentioning

confidence: 99%

Section: Soft Wearable Healthcare Devicesmentioning

confidence: 99%

Soft Wearable Healthcare Materials and Devices

Lyu

Gong

Yin

et al. 2021

Adv Healthcare Materials

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In spite of advances in electronics and internet technologies, current healthcare remains hospital‐centred. Disruptive technologies are required to translate state‐of‐art wearable devices into next‐generation patient‐centered diagnosis and therapy. In this review, recent advances in the emerging field of soft wearable materials and devices are summarized. A prerequisite for such future healthcare devices is the need of novel materials to be mechanically compliant, electrically conductive, and biologically compatible. It is begun with an overview of the two viable design strategies reported in the literatures, which is followed by description of state‐of‐the‐art wearable healthcare devices for monitoring physical, electrophysiological, chemical, and biological signals. Self‐powered wearable bioenergy devices are also covered and sensing systems, as well as feedback‐controlled wearable closed‐loop biodiagnostic and therapy systems. Finally, it is concluded with an overall summary and future perspective.

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“…Polypyrrole based gold screen printed electrode (enzyme labelled) TNF-␣, bovine calf serum Potentiometric 10 pg/ml, compared with commercial ELISA [12] Gold interdigitated electrode capacitor arrays TNF-␣, PBS Label-free capacitance measurements 32 pg/ml [13] Affinity based gold electrode functionalized using CMA TNF-␣, artificial saliva, human saliva Chronoamperometry 1 pg/ml [14] Stretchable and disposable 3D micropatterned elastomer-based electrode TNF-␣, human serum Electrochemical (potentiometric and impedimetric) 100 fM [15] Label-free chronobiology tracking system Cortisol, sweat Impedimetric 1 ng/ml [16] MoS2 nanosheet based flexible electrode Cortisol, sweat Impedimetric 1 ng/ml [17] CMA: Carboxymethylaniline; ELISA: Enzyme-linked immunosorbent assay; LOD: Limit of detection; MoS2: Molybdenum disulphide; PBS: Phosphate-buffered saline.…”

Section: Sensor Description Biomarker and Biofluidmentioning

confidence: 99%

Point-of-Use Sweat Biosensor to Track the Endocrine–Inflammation Relationship for Chronic Disease Monitoring

et al. 2020

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Aim: The hypothalamic–pituitary–adrenal axis is involved in maintaining homeostasis by engaging with the parasympathetic nervous system. During the process of disease affliction, this relationship is disturbed and there is an imbalance driven response observed. Materials & methods: By monitoring the two key components involved in these pathways, cortisol and TNF-α, the manifestations of chronic stress on the body’s homeostasis can be evaluated in a comprehensive manner. This work highlights the development of an electrochemical detection system for the two biomarkers through human sweat. Results: Limit of detection and dynamic ranges are 1 ng/ml, 1–200 ng/ml for cortisol and 1 pg/ml, 1–1000 pg/ml for TNF-α. Conclusion: This wearable system is designed to be a point of use, chronic disease self-monitoring and management platform.

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A durable, stretchable, and disposable electrochemical biosensor on three-dimensional micro-patterned stretchable substrate

Cited by 39 publications

References 45 publications

Wearable Biosensors for Non-Invasive Sweat Diagnostics

Wearable Biosensors for Non-Invasive Sweat Diagnostics

Soft Wearable Healthcare Materials and Devices

Point-of-Use Sweat Biosensor to Track the Endocrine–Inflammation Relationship for Chronic Disease Monitoring

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