A dumbbell-like supramolecular triblock copolymer and its self-assembly of light-responsive vesicles

Zhang, Dapeng; Fan, Yujiao; Li, Huimei; Li, Ké; Yao, Yuan; Zhou, Yongfeng; Yan, Deyue

doi:10.1039/c5ra08661b

Cited by 19 publications

(10 citation statements)

References 68 publications

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“…An additional example of complex supramolecular ABA block copolymers was published by Yanand co-workers,who connected a b-CD-centered hyperbranched poly(glycerol) (HPG) star with PS that was doubly end functionalized with azobenzene. [65] ApH-/CO 2 -responsive ABC block copolymer was described by Yuan and co-workers. [66] Here,apoly(ecaprolactone) (PCL) and b-CD end functionalized poly [2-(dimethylamino)ethyl methacrylate] (PDMAEMA) were connected to form ac ovalently bound diblock copolymer, which was further utilized to form as upramolecular block copolymer with adamantyl-functionalized PNIPAM.…”

Section: Higher Order Block Copolymersmentioning

confidence: 99%

“…The aggregate structures formed on heating showed a strong dependence on the stoichiometry, as the ratio of hydrophilic and hydrophobic units after heating is directly related to the number of equivalents of the individual building blocks used. An additional example of complex supramolecular ABA block copolymers was published by Yan and co‐workers, who connected a β‐CD‐centered hyperbranched poly(glycerol) (HPG) star with PS that was doubly end functionalized with azobenzene . A pH‐/CO 2 ‐responsive ABC block copolymer was described by Yuan and co‐workers .…”

Section: The Secondary Structure: Supramolecular Self‐assembliesmentioning

confidence: 99%

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Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

2017

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Dynamic and adaptive materials are powerful constructs in macromolecular and polymer chemistry with a wide array of applications in drug delivery, bioactive systems, and self‐healing materials. Very often, dynamic materials are based on carefully tailored cyclodextrin host–guest interactions. The precise incorporation of these host and guest moieties into macromolecular building blocks allows the formation of complex macromolecular structures with predefined functions. Thus, dynamic materials with extraordinary adaptive property profiles—responsive to thermal, chemical, and photonic fields—become accessible. This Review explores the hierarchical formation of dynamic materials and complex macromolecular structures from the molecular via the macromolecular to the colloidal and macroscopic level, with a specific emphasis on the functionality and responsiveness of the assemblies, specifically in biological contexts.

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Section: Higher Order Block Copolymersmentioning

confidence: 99%

Section: The Secondary Structure: Supramolecular Self‐assembliesmentioning

confidence: 99%

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

2017

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“…Compared to the conventional polymeric vesicles, supramolecular vesicles mediated by host–guest interactions are more interesting since the inclusion can be designed to be stimuli‐responsive (e.g., light‐responsive, CO 2 ‐responsive, pH‐responsive, magnetic‐responsive, redox‐responsive, mechanical‐responsive, voltage‐responsive, chemical‐responsive, dual‐responsive, multiresponsive). Therefore, supramolecular vesicles as “smart” materials are suitable for application in nanocontainers, drug delivery, and biomedicine .…”

Section: Introductionmentioning

confidence: 99%

UV-Responsive Supramolecular Vesicles with Double Hydrophobic Chains

Zhang

Dai

Chen

et al. 2016

Macromol. Rapid Commun.

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In order to improve the stability of polymeric vesicles, supramolecular vesicles are developed via self-assembly of the inclusion of γ-cyclodextrin (γ-CD) and 1-pyrenemethyl palmitate (Py-pal). The inclusion has one hydrophilic head and double hydrophobic tails, which looks like the phospholipid. From the transmission electron microscopy (TEM) image, it can be observed that the average diameter of supramolecular vesicles is approximately 55 nm and there is a huge cavity in supramolecular vesicles. Due to the photo-breakable ester of Py-pal, supramolecular vesicles are broken under UV irradiation. Supramolecular vesicles are used as UV-responsive drug carriers to release the hydrophilic drug such as doxorubicin hydrochloride (DOX•HCl).

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“…These controllable topological structures consist of micelles 50 - 52 , vesicles 53 - 57 , nanofibers 52 , nanometer/micrometer-sized tubes 58 , 59 , giant vesicles 60 , 61 , ribbons 62 , 63 , films 64 , 65 , macroscopic tubes 49 , gels 66 , etc.. For instance, the hyperbranched poly[3-ethyl-3-(hydroxymethyl)oxetane]- star -poly(propylene oxide) (PEHO- star -PPO) prepared by Yan and coworkers can aggregate into large regular spherical micelles with controlled size via the alteration of the molar ratios of PPO arms to PEHO core 50 . Dendritic polymers can also self-assemble into vesicles with narrow size distribution.…”

Section: Introductionmentioning

confidence: 99%

Dendritic Polymers for Theranostics

et al. 2016

Self Cite

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Dendritic polymers are highly branched polymers with controllable structures, which possess a large population of terminal functional groups, low solution or melt viscosity, and good solubility. Their size, degree of branching and functionality can be adjusted and controlled through the synthetic procedures. These tunable structures correspond to application-related properties, such as biodegradability, biocompatibility, stimuli-responsiveness and self-assembly ability, which are the key points for theranostic applications, including chemotherapeutic theranostics, biotherapeutic theranostics, phototherapeutic theranostics, radiotherapeutic theranostics and combined therapeutic theranostics. Up to now, significant progress has been made for the dendritic polymers in solving some of the fundamental and technical questions toward their theranostic applications. In this review, we briefly summarize how to control the structures of dendritic polymers, the theranostics-related properties derived from their structures and their theranostics-related applications.

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A dumbbell-like supramolecular triblock copolymer and its self-assembly of light-responsive vesicles

Abstract: The work reports a dumbbell-like supramolecular triblock copolymer and its self-assembly of light-responsive monolayer vesicles.

Cited by 19 publications

References 68 publications

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

UV-Responsive Supramolecular Vesicles with Double Hydrophobic Chains

Dendritic Polymers for Theranostics

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