A dual-template imprinted polymer based on amino-functionalized zirconium-based metal–organic framework for delivery of doxorubicin and phycocyanin with synergistic anticancer effect

Han, Song‐De; Yao, Aixin; Ding, Yuxin; Leng, Qiuxue; Fu, Teng; Zhao, Le; Sun, Ruonan; Bu, Hongzhou

doi:10.1016/j.eurpolymj.2022.111161

Cited by 19 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has recently received significant attention owing to its high selectivity and sensitivity toward targets. Applications of MIP have been demonstrated in drug delivery, , solid-phase extraction coupled with liquid chromatography, , catalysis, , and environmental and biomedical sensing. − Various techniques have been utilized to synthesize MIP layers, including free-radical polymerization, chemical grafting, soft lithographies, molecular self-assembly, and electropolymerization. , Among these techniques, electropolymerization is a practical approach for MIP synthesis because a target molecule can be added to the electrolyte and entrapped in a conductive polymeric film. The molecules are sequentially extracted or leached out of the external polymeric surfaces to create recognition sites for MIP.…”

Section: Introductionmentioning

confidence: 99%

“…It has recently received significant attention owing to its high selectivity and sensitivity toward targets. Applications of MIP have been demonstrated in drug delivery, 7 , 8 solid-phase extraction coupled with liquid chromatography, 9 , 10 catalysis, 11 , 12 and environmental and biomedical sensing. 13 − 15 Various techniques have been utilized to synthesize MIP layers, including free-radical polymerization, chemical grafting, 16 soft lithographies, 17 molecular self-assembly, 18 and electropolymerization.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical Sensor Based on a Composite of Reduced Graphene Oxide and Molecularly Imprinted Copolymer of Polyaniline–Poly(o-phenylenediamine) for Ciprofloxacin Determination: Fabrication, Characterization, and Performance Evaluation

et al. 2023

View full text Add to dashboard Cite

Contamination of antibiotics in water is a major cause of antibiotic resistance (ABR) in pathogens that endangers human health and food security worldwide. Ciprofloxacin (CIP) is a synthetic fluoroquinolone (FQ) antibiotic and is reportedly present in surface water at a concentration exceeding the ecotoxicological predicted no-effect concentration in some areas. This study fabricated a CIP sensor using an electropolymerized molecularly imprinted polymer (MIP) of polyaniline (PANI) and poly(o-phenylenediamine) (o-PDA) with CIP recognition sites. The MIP was coated on a reduced graphene oxide (rGO)modified glassy carbon electrode (rGO/GCE) and operated under a differential pulse voltammetry (DPV) mode for CIP detection. The sensor exhibited an excellent response from 1.0 × 10 −9 to 5.0 × 10 −7 mol L −1 CIP, showing a sensor detection limit and sensitivity of 5.28 × 10 −11 mol L −1 and 5.78 μA mol −1 L, respectively. The sensor's sensitivity for CIP was 1.5 times higher than that of the other tested antibiotics, including enrofloxacin (ENR), ofloxacin (OFX), sulfamethoxazole (SMZ), and piperacillin sodium salt (PIP). The reproducibility and reusability of the sensor devices were also studied.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensor Based on a Composite of Reduced Graphene Oxide and Molecularly Imprinted Copolymer of Polyaniline–Poly(o-phenylenediamine) for Ciprofloxacin Determination: Fabrication, Characterization, and Performance Evaluation

et al. 2023

View full text Add to dashboard Cite

show abstract

“…[ 8 ] In the present study, to protect the drug from premature diffusion and enhance the active targeting capacity of these SS‐DMONs, we used a molecular imprinting technique (MIT) to prepare molecularly imprinted polymers (MIPs) on the surface of SS‐DMONs. MIT is widely used in the preparation of economical, stable, and biocompatible MIPs, [ 9 ] which possess elective binding sites and can be used to identify various biological materials, including amino acids, glycans, genetic materials, and cells. [ 10 ] Another important advantage of MIPs is that, in contrast to other nanoparticle therapies, given their targeted cavities, these polymers do not require the modification of targeted ligands, which is thus comparable to natural biorecognition systems, such as enzyme‐substrate and antigen‐antibody.…”

Section: Introductionmentioning

confidence: 99%

Disulfide‐Bridged Dendritic Organosilicas‐Based Biodegradable Molecularly Imprinted Polymers for Multiple Targeting and pH/Redox‐Responsive Drug Release toward Chemical/Photodynamic Synergistic Tumor Therapy

Liu

Han

Song

et al. 2023

Adv Healthcare Materials

Self Cite

View full text Add to dashboard Cite

In this study, a sialic acid (SA) and transferrin (TF) imprinted biodegradable disulfide bridging organosilicas‐based drug delivery system (SS‐DMONS/DOX‐Ce6@MIPs) for targeted cancer therapy is constructed, for the first time. Disulfide bridged dendritic mesoporous organosilicas nanoparticles (SS‐DMONs) not only enhance drug loading as the drug repository, but also provide enough specific surface area for the molecular imprinting shell to expose more degradation and imprinted sites on the surface. In addition, SS can be disturbed in a highly reducing tumor microenvironment to achieve degradation. The biodegradable imprinting film, prepared with customized 2‐amino‐N‐(3,4‐dihydroxyphenethyl)‐3‐mercaptopropanamide and 4‐mercaptophenylboronic acid as functional monomers, endows SS‐DMONs with active targeting capacity, and responsive drug release through degradation under acidic and highly reductive tumor microenvironment. SS‐DMONS/DOX‐Ce6@MIPs after binding of TF can target tumor cells actively through multiple interactions, including the affinity between antigen and antibody, and the specific recognition between molecularly imprinted polymers and template molecules. Under laser irradiation the loaded chlorin e6 (Ce6) that can produce toxic reactive oxygen, combined with the doxorubicin (DOX), achieves chemical/photodynamic synergistic anticancer effects. SS‐DMONS/DOX‐Ce6@MIPs present excellent tumor targeting and dual‐responsive drug release, which provides an effective strategy for chemical/photodynamic antitumor therapy.

show abstract

“…LC@UiO-66 showed a sustained release performance and excellent bioactivity against Musca domestica and Aphis craccivora Koch . In addition, UiO-66 has been used in anticancer drug delivery, biomedicine, and environmental sewage remediation, exhibiting excellent biocompatibility and environmental safety. − …”

Section: Introductionmentioning

confidence: 99%

Metal–Organic Framework (UiO-66)-Based Temperature-Responsive Pesticide Delivery System for Controlled Release and Enhanced Insecticidal Performance against Spodoptera frugiperda

Wan

Song

Feng

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Spodoptera frugiperda is a global pest that brings about great disasters to crops. Conventional pesticide formulations often suffer from poor water solubility, low stability, burst release, weak leaf adhesion, and low efficiency. To improve the insecticidal activity of pesticides, a stimuli-responsive controlled release pesticide delivery system (PDS) has attracted extensive attention in recent years. This paper reports a temperatureresponsive controlled release PDS based on poly(N-isopropyl acrylamide) (PNIPAm)modified indoxacarb (IDC)-loaded UiO-66-(COOH) 2 (IDC@UiO-66-(COOH) 2 -PNI-PAm) and studies its insecticidal activities against S. frugiperda. The UiO-66-(COOH) 2 nanocarrier has an excellent pesticide loading performance, and the loading rate for IDC is 78.69%. The as-prepared PDS has good stability, temperature-responsive controllable release performance, and enhanced leaf affinity, so it can effectively improve the utilization rate of IDC. The insecticidal experiment indicates that the PDS has an enhanced control effect against S. frugiperda. In addition, biosafety analysis further verifies that the PDS exhibits no obvious negative effects on the germination of maize seeds and the growth of maize seedlings. In view of this, we believe that this PDS will have a broad application in the field of pesticide formulation innovation, pest management, and sustainable agricultural development.

show abstract

A dual-template imprinted polymer based on amino-functionalized zirconium-based metal–organic framework for delivery of doxorubicin and phycocyanin with synergistic anticancer effect

Cited by 19 publications

References 41 publications

Electrochemical Sensor Based on a Composite of Reduced Graphene Oxide and Molecularly Imprinted Copolymer of Polyaniline–Poly(o-phenylenediamine) for Ciprofloxacin Determination: Fabrication, Characterization, and Performance Evaluation

Electrochemical Sensor Based on a Composite of Reduced Graphene Oxide and Molecularly Imprinted Copolymer of Polyaniline–Poly(o-phenylenediamine) for Ciprofloxacin Determination: Fabrication, Characterization, and Performance Evaluation

Disulfide‐Bridged Dendritic Organosilicas‐Based Biodegradable Molecularly Imprinted Polymers for Multiple Targeting and pH/Redox‐Responsive Drug Release toward Chemical/Photodynamic Synergistic Tumor Therapy

Metal–Organic Framework (UiO-66)-Based Temperature-Responsive Pesticide Delivery System for Controlled Release and Enhanced Insecticidal Performance against Spodoptera frugiperda

Contact Info

Product

Resources

About