A Dual Spectroscopic Probe Based on Benzothiazole for Detection of Hydrazine

Abstract

Hydrazine is widely used in fuels, fuel cell reactors and the synthesis of polymer, drug and pesticide intermediates. However, it can be contained in food and drinking water and enter organisms through the food chains because of its good water solubility, causing serious health problems. Therefore, there is an urgent need to develop new analytical reagents to detect hydrazine with high selectivity and sensitivity. In this paper, a spectroscopic probe (probe 1) for hydrazine hydrate based on the addition‐cyclization mechanism with high selectivity and sensitivity was developed. This probe can simultaneously detect hydrazine by UV‐visible and fluorescence spectra, and the corresponding detection limits are 51.7 μM and 6.7 nM, respectively. Importantly, the spectroscopic probe was successfully applied to hydrazine detection in water samples and living cells. The test strips based on the probe was also prepared for the point‐of‐care testing of hydrazine in the actual water samples.

An AIE-active tetra-aryl imidazole-derived chemodosimeter for turn-on recognition of hydrazine and its bioimaging in living cells

“…At present, most fluorescent probes for the detection of hydrazine are based on the following reaction mechanisms: nucleophilic substitution of hydrazine for methyl-enemalononitrile, [11][12][13][14] condensation of hydrazine and aldehydes or ketones, 15 deprotection of acetyl groups and their derivatives, [16][17][18] and hydrazine-induced cyclization or ringopening reactions. [19][20][21][22] Unfortunately, the fluorescence of these hydrazine identification probes is easily quenched in aqueous solutions or in the solid state due to the aggregationcaused quenching (ACQ) effect, which greatly limits their application. In 2001, Tang's team 23 reported the phenomenon of aggregation-induced emission (AIE), which effectively addresses the defects present in ACQ fluorescent probes.…”