A dual-signals response electrochemiluminescence immunosensor based on PTC-DEPA/KCC-1 NCs for detection of procalcitonin

Chen, Peipei; Qiao, Xueying; Liu, Jianhui; Xia, Fangquan; Tian, Dong; Zhou, Changli

doi:10.1016/j.snb.2018.04.061

Cited by 20 publications

(11 citation statements)

References 37 publications

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“…12-14 KCC-1 has shown its broad prospects in energy, 15,16 environmental governance, 17,18 catalysis, 19,20 and sensors. 21,22 Because of the abundant silanol groups on the surface of KCC-1 and highly porous surface, it is a good carrier for surface molecularly imprinted polymers. There are no reports on the use of KCC-1 as a surface imprinting body.…”

Section: Introductionmentioning

confidence: 99%

Preparation and application of methimazole molecularly imprinted polymer based on silver-loaded dendritic fiber-type silica

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Preparation and application of methimazole molecularly imprinted polymer based on silver-loaded dendritic fiber-type silica

et al. 2021

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“…Up to now, many detection methods based on immunoassay have been developed for PCT determination; for instance, enzyme-linked immunosorbent assay [ 9 ], chemiluminescence immunoassay [ 10 , 11 ], electrochemical immunoassay [ 12 , 13 , 14 ], microfluidics immunoassays [ 15 ], fluorescence immunoassay [ 16 ], lateral flow immunoassays [ 17 ], surface plasma resonance immunoassay [ 18 ], photoelectrochemical (PEC) immunosensor [ 19 , 20 ] and so on. Compared with other methods, PEC immunosensors have excellent features of high signal-to-noise ratio, simple operation, needlessness of expensive maintenance and easy miniaturization because of the dual advantages of optical and electrochemical methods.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO2/BiOI/Ag2S Composites for Detection of Procalcitonin

et al. 2021

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Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO2 porous nanoflowers with good photocatalytic performance were prepared by combining hydrothermal synthesis and calcining. BiOI nanoflowers were synthesized by facile ultrasonic mixed reaction. Ag2S quantum dots were deposited on SnO2/BiOI composites by in situ growth method. The SnO2/BiOI/Ag2S composites with excellent photoelectric properties were employed as substrate material, which could provide significantly enhanced and stable signal because of the energy level matching of SnO2, BiOI and Ag2S and the good light absorption performance. Accordingly, a PEC immunosensor based on SnO2/BiOI/Ag2S was constructed by using the layered modification method to achieve high sensitivity analysis of PCT. The linear dynamic range of the detection method was 0.50 pg·mL−1~100 ng·mL−1, and the detection limit was 0.14 pg·mL−1. In addition, the designed PEC immunosensor exhibited satisfactory sensitivity, selectivity, stability and repeatability, which opened up a new avenue for the analyzation of PCT and further provided guidance for antibiotic therapy.

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“…Several methods have been reported for PCT determination, mainly based in the selective recognition provided by immunological interactions. These methodologies include immunoturbidimetric assays [9], chemiluminescent immunoassays [10][11][12][13][14][15][16], immunochromatographic assays [17][18][19][20][21][22], surface plasmon resonance biosensors [23][24][25], fluorescence immunosensors [26][27][28][29][30][31][32], ellipsometry immunosensors [33], colorimetric immunoassays [34][35][36], and electrochemical immunoassays [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56]. Even differen...…”

Section: Introductionmentioning

confidence: 99%

Magnetic Bead-Based Electrochemical Immunoassays On-Drop and On-Chip for Procalcitonin Determination: Disposable Tools for Clinical Sepsis Diagnosis

et al. 2020

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Procalcitonin (PCT) is a known protein biomarker clinically used for the early stages of sepsis diagnosis and therapy guidance. For its reliable determination, sandwich format magnetic bead-based immunoassays with two different electrochemical detection approaches are described: (i) disposable screen-printed carbon electrodes (SPE-C, on-drop detection); (ii) electro-kinetically driven microfluidic chips with integrated Au electrodes (EMC-Au, on-chip detection). Both approaches exhibited enough sensitivity (limit of detection (LOD) of 0.1 and 0.04 ng mL−1 for SPE-C and EMC-Au, respectively; cutoff 0.5 ng mL−1), an adequate working range for the clinically relevant concentrations (0.5–1000 and 0.1–20 ng mL−1 for SPE-C and EMC-Au, respectively), and good precision (RSD < 9%), using low sample volumes (25 µL) with total assay times less than 20 min. The suitability of both approaches was successfully demonstrated by the analysis of human serum and plasma samples, for which good recoveries were obtained (89–120%). Furthermore, the EMC-Au approach enabled the easy automation of the process, constituting a reliable alternative diagnostic tool for on-site/bed-site clinical analysis.

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A dual-signals response electrochemiluminescence immunosensor based on PTC-DEPA/KCC-1 NCs for detection of procalcitonin

Cited by 20 publications

References 37 publications

Preparation and application of methimazole molecularly imprinted polymer based on silver-loaded dendritic fiber-type silica

Preparation and application of methimazole molecularly imprinted polymer based on silver-loaded dendritic fiber-type silica

Ultrasensitive Photochemical Immunosensor Based on Flowerlike SnO2/BiOI/Ag2S Composites for Detection of Procalcitonin

Magnetic Bead-Based Electrochemical Immunoassays On-Drop and On-Chip for Procalcitonin Determination: Disposable Tools for Clinical Sepsis Diagnosis

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