A dual signal-amplified electrochemiluminescence immunosensor based on core-shell CeO2-Au@Pt nanosphere for procalcitonin detection

Shao, Xinrong; Song, Xianzhen; Liu, Xin; Yan, Liangguo; Liu, Lei; Fan, Dawei; Wei, Qin; Ju, Huangxian

doi:10.1007/s00604-021-04988-7

Cited by 11 publications

(4 citation statements)

References 47 publications

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“…Therefore, accurate detection of PCT is crucial for effective early diagnosis. [8][9][10] Currently, common detection techniques for PCT include chemiluminescent immunoassay (CLIA), fluorescent immuno-assay (IFA), and enzyme-linked immunosorbent assay (ELISA). [11][12][13][14][15][16][17][18] These immunosensors are distinguished with specific analytes targeting and are also applied in various biomolecules sensing.…”

Section: Introductionmentioning

confidence: 99%

“…Monitoring PCT concentrations not only provides useful information for the differential diagnosis of infectious diseases but also helps to avoid antibiotic misuse, reduce the occurrence of resistance, and improve the diagnostic success rate for patients with infection and systemic inflammatory responses. Therefore, accurate detection of PCT is crucial for effective early diagnosis [8–10] …”

Section: Introductionmentioning

confidence: 99%

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Construction of AuNPs/UiO‐66−NH₂ Decorated Microcantilever Immunosensor for Efficient Detection of Procalcitonin

Leng,

Zhang,

Zhang

et al. 2023

ChemistrySelect

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In this study, gold nanoparticles (AuNPs) were grown on the surface of a metal‐organic framework (UiO‐66−NH2). The resulting AuNPs/UiO‐66−NH2 composite nanomaterials were further used for antibody immobilization on a microcantilever surface. By harnessing the robust signal processing capabilities of integrated circuits, a highly sensitive piezoelectric microcantilever sensor was constructed. The incorporation of nanomaterials resulted in enhanced antibodies immobilization amount, thereby improving the immunosensor‘s sensitivity. Under optimized experimental conditions, a promising linear correlation (R=0.993) was observed between the voltage output intensity of the microcantilever sensor and the logarithmic PCT concentration within a range of 0.1–50 ng/mL. The constructed microcantilever immunosensor based displayed several advantages such as simplicity, rapidity, high sensitivity, and low cost. Moreover, it potentially provided a novel approach to detect other biomolecules.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Construction of AuNPs/UiO‐66−NH₂ Decorated Microcantilever Immunosensor for Efficient Detection of Procalcitonin

Leng,

Zhang,

Zhang

et al. 2023

ChemistrySelect

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show abstract

“…Procalcitonin (PCT), an environmental-friendly biomarker of a variety of diseases induced by bacterial infections, has already played a significant role in clinical medicine practice [1][2][3][4][5]. Currently, various detection methods have been developed for PCT quantitative detection, such as enzyme-linked immunosorbent assays (ELISA) [6,7], protein microarrays [8][9][10], electrochemiluminescent immunosensors [11][12][13], surface plasmon resonance biosensors [14][15][16] and electrochemical biosensors [17][18][19]. Compared with other methods, the electrochemical biosensor is an effective analytical approach, and it has attracted great interest owing to its advantages of high sensitivity and selectivity, rapid response, low cost and easy miniaturization [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

NiCoP/g-C3N4 Nanocomposites-Based Electrochemical Immunosensor for Sensitive Detection of Procalcitonin

Chen¹,

Bao²,

Zhang³

et al. 2023

Sensors

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Herein, an ultra-sensitive and facile electrochemical biosensor for procalcitonin (PCT) detection was developed based on NiCoP/g-C3N4 nanocomposites. Firstly, NiCoP/g-C3N4 nanocomposites were synthesized using hydrothermal methods and then functionalized on the electrode surface by π-π stacking. Afterward, the monoclonal antibody that can specifically capture the PCT was successfully linked onto the surface of the nanocomposites with a 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-Hydroxysuccinimide (NHS) condensation reaction. Finally, the modified sensor was employed for the electrochemical analysis of PCT using differential Pulse Voltammetry(DPV). Notably, the larger surface area of g-C3N4 and the higher electron transfer capacity of NiCoP/g-C3N4 endow this sensor with a wider detection range (1 ag/mL to 10 ng/mL) and an ultra-low limit of detection (0.6 ag/mL, S/N = 3). In addition, this strategy was also successfully applied to the detection of PCT in the diluted human serum sample, demonstrating that the developed immunosensors have the potential for application in clinical testing.

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“…15 Electrochemiluminescence (ECL) is a multifunctional analytical technique that converts electric energy into light energy. [16][17][18] The excited state of the substances produced on the electrode surface is formed by electron transfer, which is a special chemiluminescence phenomenon on the electrode. 19,20 Therefore, it is an ideal combination of electrochemistry and spectroscopy, and it has been widely used in diagnosis, analysis and environmental detection for its unique performance.…”

Section: Introductionmentioning

confidence: 99%

ZnCdS enhanced g-C₃N₄ electrochemiluminescence behavior based on Rh_0.6Ru_0.4@Ag quenching for neuron-specific enolase detection

et al. 2022

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A dual signal-amplified electrochemiluminescence immunosensor based on core-shell CeO2-Au@Pt nanosphere for procalcitonin detection

Cited by 11 publications

References 47 publications

Construction of AuNPs/UiO‐66−NH₂ Decorated Microcantilever Immunosensor for Efficient Detection of Procalcitonin

Construction of AuNPs/UiO‐66−NH₂ Decorated Microcantilever Immunosensor for Efficient Detection of Procalcitonin

NiCoP/g-C3N4 Nanocomposites-Based Electrochemical Immunosensor for Sensitive Detection of Procalcitonin

ZnCdS enhanced g-C₃N₄ electrochemiluminescence behavior based on Rh_0.6Ru_0.4@Ag quenching for neuron-specific enolase detection

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A dual signal-amplified electrochemiluminescence immunosensor based on core-shell CeO2-Au@Pt nanosphere for procalcitonin detection

Cited by 11 publications

References 47 publications

Construction of AuNPs/UiO‐66−NH2 Decorated Microcantilever Immunosensor for Efficient Detection of Procalcitonin

Construction of AuNPs/UiO‐66−NH2 Decorated Microcantilever Immunosensor for Efficient Detection of Procalcitonin

NiCoP/g-C3N4 Nanocomposites-Based Electrochemical Immunosensor for Sensitive Detection of Procalcitonin

ZnCdS enhanced g-C3N4 electrochemiluminescence behavior based on Rh0.6Ru0.4@Ag quenching for neuron-specific enolase detection

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Construction of AuNPs/UiO‐66−NH₂ Decorated Microcantilever Immunosensor for Efficient Detection of Procalcitonin

Construction of AuNPs/UiO‐66−NH₂ Decorated Microcantilever Immunosensor for Efficient Detection of Procalcitonin

ZnCdS enhanced g-C₃N₄ electrochemiluminescence behavior based on Rh_0.6Ru_0.4@Ag quenching for neuron-specific enolase detection