A dual-responsive nanozyme sensor with ultra-high sensitivity and ultra-low cross-interference towards metabolic biomarker monitoring

Wang, Xinyu; Xia, Zhaoping; Fodjo, Essy Kouadio; Deng, Wei; Li, Dan

doi:10.1039/d1tb02796d

Cited by 11 publications

(13 citation statements)

References 38 publications

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“…173 By employing diverse nanostructured surfaces or probes, simultaneous detection of multiple target molecules and multichannel imaging can be achieved. [174][175][176] However, SERS imaging encounters challenges associated with the stability of nanostructured surfaces. Prolonged laser irradiation or changes in experimental conditions can induce morphological alterations that may compromise the stability and accuracy of SERS signals.…”

Section: Sersmentioning

confidence: 99%

Engineered aptamers for molecular imaging

Lin,

Xiao,

Jiang

et al. 2023

Chem. Sci.

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Section: Sersmentioning

confidence: 99%

Engineered aptamers for molecular imaging

Lin,

Xiao,

Jiang

et al. 2023

Chem. Sci.

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“…Unfortunately, the blood collection procedure often involves or triggers tissue damage, potential infection, and unavoidable pain [ 9 , 10 ]. Other biofluids (e.g., urine, saliva, sweat, and tears) are usually limited by their poor correlation with diseases due to the significantly variable levels of biomarkers [ 11 , 12 ]. Nowadays, skin interstitial fluid (ISF), which originates from capillary filtration through blood to the intercellular substance of the dermis, has emerged as an alternative biofluid source to blood serum and plasma for medical diagnosis and disease therapy [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Microneedle-Integrated Sensors for Extraction of Skin Interstitial Fluid and Metabolic Analysis

Yang

Luo

Yang

et al. 2023

IJMS

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Skin interstitial fluid (ISF) has emerged as a fungible biofluid sample for blood serum and plasma for disease diagnosis and therapy. The sampling of skin ISF is highly desirable considering its easy accessibility, no damage to blood vessels, and reduced risk of infection. Particularly, skin ISF can be sampled using microneedle (MN)-based platforms in the skin tissues, which exhibit multiple advantages including minimal invasion of the skin tissues, less pain, ease of carrying, capacity for continuous monitoring, etc. In this review, we focus on the current development of microneedle-integrated transdermal sensors for collecting ISF and detecting specific disease biomarkers. Firstly, we discussed and classified microneedles according to their structural design, including solid MNs, hollow MNs, porous MNs, and coated MNs. Subsequently, we elaborate on the construction of MN-integrated sensors for metabolic analysis with highlights on the electrochemical, fluorescent, chemical chromogenic, immunodiagnostic, and molecular diagnostic MN-integrated sensors. Finally, we discuss the current challenges and future direction for developing MN-based platforms for ISF extraction and sensing applications.

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“…Nanozymes with inherent enzyme-like properties are regarded as excellent substitutes for natural enzymes and have attracted a lot of attention [3,4]. Various nanomaterials such as metal-organic frameworks (MOFs), metal oxides, and carbon materials have presented attractive artificial antioxidant enzymes features [5][6][7][8] and have been extensively implemented in bionics, biomedicine, biological sensing, and environmental science [9][10][11][12][13][14][15][16][17][18][19]. These nanomaterials can regulate the redox levels of cells by mimicking the catalytic processes of natural enzymes such as peroxidase (POD), catalase (CAT), and glutathione peroxidase (GPx).…”

Section: Introductionmentioning

confidence: 99%

‘Switch to love, switch to kill—dose and light co-regulate iron single-atom nanozyme to modulate cell fate

Zhe¹,

Liu²,

Zhao³

et al. 2022

Nanotechnology

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Remote control of cells and the regulation of cell events at the molecular level are of great interest to the biomedical field. In addition to mechanical forces and genes, chemical compounds and light play pivotal roles in regulating cell fate, which have boosted the fast growth of biology. Herein, we synthesized light-regulated, atomically dispersed Fe-N4 immobilized on a carbon substrate nanozyme (Fe-N/C single atom catalysts), whose peroxidase- and catalase-like properties can be enhanced by 120% and 135%, respectively, under 808-nm laser irradiation through the photothermal effect of Fe-N/C. Interestingly, a switch to love/switch to kill interaction between Fe-N/C dose and near-infrared (NIR) light co-regulating the Fe-N/C nanozyme to modulate cell fate was discovered. Based on this, we found that under NIR light irradiation, when the dose of Fe-N/C is low, it can scavenge more reactive oxygen species (ROS) and achieve cell protection; when the dose of Fe-N/C is too high, it tended to lead to cell apoptosis. This work not only provides an effective strategy for the regulation of nanozyme activity but also realises the dual-functional application of nanozyme materials for the treatment of some specific diseases.

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A dual-responsive nanozyme sensor with ultra-high sensitivity and ultra-low cross-interference towards metabolic biomarker monitoring

Abstract: Accurate, sensitive and selective detection of metabolic biomarkers in biofluids are of vital significance for health self-monitoring and chronic disease prevention. Here, for the first time, a smart dual-responsive nanozyme...

Cited by 11 publications

References 38 publications

Engineered aptamers for molecular imaging

Engineered aptamers for molecular imaging

Microneedle-Integrated Sensors for Extraction of Skin Interstitial Fluid and Metabolic Analysis

‘Switch to love, switch to kill—dose and light co-regulate iron single-atom nanozyme to modulate cell fate

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