A dual-response fluorescent probe for SO2 and viscosity in lysosomes

A mitochondria-specific NIR fluorescence probe for dual-detection of sulfur dioxide and viscosity in living cells and mice

“…39 These results indicated that the probe CMBT has a longer emission wavelength and excellent sensitivity to SO 2 compared to the reported literature. 8,12,13,15,18…”

“…39 These results indicated that the probe CMBT has a longer emission wavelength and excellent sensitivity to SO 2 compared to the reported literature. 8,12,13,15,18 The stability of pH is of utmost importance in biochemical applications within the system. 18,40 To evaluate the inuence of SO 2 on CMBT under diverse pH conditions, uorescence assays were conducted.…”

“…8,12,13,15,18 The stability of pH is of utmost importance in biochemical applications within the system. 18,40 To evaluate the inuence of SO 2 on CMBT under diverse pH conditions, uorescence assays were conducted. As shown in Fig.…”

“…13,14 Recent studies have suggested a correlation between abnormal endogenous sulfur dioxide derivative levels and diseases such as cancer, cardiovascular diseases, respiratory diseases, and neurological disorders. 15–18 In addition, there are increasing studies showing a close relationship between abnormal levels of mitochondrial viscosity and SO 2 in mitochondrial dysfunction. 19–21 Therefore, the development of a sensitive and effective detection method for viscosity and SO 2 in mitochondria is crucial for disease diagnosis and pathological studies.…”

Probing fluctuations in sulfur dioxide and viscosity levels during mitochondrial dysfunction using a dual-response fluorescent probe with good water solubility

“…Therefore, a few well-designed dual-response fluorescent probes have been developed to analyze SO 2 and viscosity. 39–42 However, most of these probes have drawbacks of poor water solubility, complicated synthesis, long response time, and lack of in-depth studies on SO 2 and viscosity in mitochondrial dysfunction.…”