A dual-reaction-site and dual-channel fluorescent-on probe for selectively monitoring mitochondrial glutathione

Green synthesis of carbon dots from fish scales for selective turn off–on detection of glutathione

“…The thiol-containing GSH tripeptide is used for maintaining the normal function of the human immune system. 1 GSH has many biological functions such as antioxidation, detoxification, free-radical scavenging, immunity enhancing, anti-aging, and anticancer activities. The GSH content in cells is a crucial factor in the clinical diagnosis of disease conditions such as cancer and diabetes.…”

A 1,8-naphthalimide based chemosensor for intracellular and biofluid detection of Pd2+ ions: microscopic and anticounterfeiting studies

“…1,2 As a close analogue of perylene diimide, 1,8-naphthalimide offers many excellent properties due to its ease of functionalization at different positions such as - bay (C-3, C-6), - peri (C-4, C-5), both - bay and - peri (C-3, C-4, C-5, C-6) and N -imide positions. 3 1,8-Naphthalimide has found applications in many areas of chemistry such as molecular recognition (sensing of metal ions, anions, biomolecules and neutral molecules in 50–90% aqueous medium); 4–6 imaging of biomedically relevant species in different organelles such as lysosomes, mitochondria; 7,8 tissue imaging; 9 dyes for colouring synthetic fibres, 10 mechanochromic and solvatochromic dyes; 11,12 fluorescent dyes for solar energy collectors and organic light emitting diodes, 13–15 and nematic liquid crystals for electro optical displays. 16 1,8-Naphthalimide and its metal complexes have been used in antibacterial, antifungal, antiviral, and anticancer applications and as DNA intercalators.…”

Bioimaging and Sensing Thiols In Vivo and in Tumor Tissues Based on a Near-Infrared Fluorescent Probe with Large Stokes Shift

“…As vital reactive sulfur species (RSS), intracellar thiols play a crucial role in regulating the redox balance of physiological and pathological processes [1,2]. The well-known smallmolecule biothiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), take on the mission of maintaining the normal metabolism of peroxy radicals, forming protein structures, resisting cell apoptosis, regulating metabolism, and protecting the homeostasis of cells in the organism [3,4]. A large amount of research has found that abnormal levels of the above biothiols (Cys, Hcy and GSH) can cause a series of related adverse diseases, such as changes in hair pigmentation, a slower growth rate, delayed response, excessive sleep, and skin diseases, and body obesity is closely consistent with the concentration fluctuations of Cys [5,6].…”