A dual-prodrug nanoparticle based on chitosan oligosaccharide for enhanced tumor-targeted drug delivery

Chen, Xia; Bremner, David H.; Ye, Yuhan; Lou, Jiadong; Niu, Shiwei; Zhu, Li‐Min

doi:10.1016/j.colsurfa.2021.126512

Cited by 12 publications

(8 citation statements)

References 46 publications

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“…As shown in the 1 H NMR spectrum of GN+ (SI Figure S2), apart from the clear signals observed at 2.5–5.0 ppm corresponding to the glycan portion, the peaks labeled “a” and “b” appearing at 1.0–2.5 ppm represented the protons in PMA, while its methyl group corresponded to the peak at 3.5–3.6 ppm. ,, Similarly, the peaks labeled “a” and “b” at 0.8–2.2 ppm in the spectrum of GN– (SI Figure S3) attributed to the PAA chains . The FTIR spectrum of GN+ (SI Figure S4A) showed a characteristic peak at 1731 cm –1 that was related to PMA, and the characteristic peaks of COS and Dex were consistent with previous reports. , In the spectrum of GN– (SI Figure S4B), the CO stretching vibration absorption peak were at 1561 cm –1 , and the other characteristic peaks corresponded to that of dextran . Moreover, the amino group content of GN+ was calculated through the fluorescamine method as 3.7 wt % (SI eq S1, Figure S5).…”

Section: Results and Discussionmentioning

confidence: 91%

“…33 The FTIR spectrum of GN + (SI Figure S4A) showed a characteristic peak at 1731 cm −1 that was related to PMA, and the characteristic peaks of COS and Dex were consistent with previous reports. 45,46 In the spectrum of GN− (SI Figure S4B), the CO stretching vibration absorption peak were at 1561 cm −1 , and the other characteristic peaks corresponded to that of dextran. 47 Moreover, the amino group content of GN+ was calculated through the fluorescamine method 37 as 3.7 wt % (SI eq S1, Figure S5).…”

Section: Resultsmentioning

confidence: 99%

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Cell Coding Arrays Based on Fluorescent Glycan Nanoparticles for Cell Line Identification and Cell Contamination Evaluation

Cheng

Liu

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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Cell lines are applied on a large scale in the field of biomedicine, but they are susceptible to issues such as misidentification and cross-contamination. This situation is becoming worse over time due to the rapid growth of the biomedical field, and thus there is an urgent need for a more effective strategy to address the problem. As described herein, a cell coding method is established based on two types of uniform and stable glycan nanoparticles that are synthesized using the graft-copolymerization-induced self-assembly (GISA) method, which further exhibit distinct fluorescent properties due to elaborate modification with fluorescent labeling molecules. The different affinity between each nanoparticle and various cell lines results in clearly distinguishable differences in their endocytosis degrees, thus resulting in distinct characteristic fluorescence intensities. Through flow cytometry measurements, the specific signals of each cell sample can be recorded and turned into a map divided into different regions by statistical processing. Using this sensing array strategy, we have successfully identified six human cell lines, including one normal type and five tumor types. Moreover, cell contamination evaluation of different cell lines with HeLa cells as the contaminant in a semiquantitative analysis has also been successfully achieved. Notably, the whole process of nanoparticle fabrication and fluorescent testing is facile and the results are highly reliable.

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Section: Results and Discussionmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Cell Coding Arrays Based on Fluorescent Glycan Nanoparticles for Cell Line Identification and Cell Contamination Evaluation

Cheng

Liu

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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“…The microenvironment in which a tumor is located has many different characteristics than that in normal physiological tissue [95]. Tumor microenvironment-based pH-based nanoparticles are one of the most studied stimulus-responsive drug nanocarriers and are sensitive to acidic environments inside and outside tumor cells [96][97][98].…”

Section: Tumor-targeted Drug Systemsmentioning

confidence: 99%

“…Xia Chen et al [95] reported a preparation method of dual prodrug nanoparticles based on COSs for enhanced tumor targeted drug delivery. Nanoparticles can effectively target CD44 receptors on the surface of tumor cells, and DOX and oleanolic acid (OA) can be released from the nanoparticles in a sustainable and pH-responsive manner, thus enabling specific drug release triggers in the tumor microenvironment.…”

Section: Tumor-targeted Drug Systemsmentioning

confidence: 99%

The Microstructure, Antibacterial and Antitumor Activities of Chitosan Oligosaccharides and Derivatives

Feng

You

et al. 2022

Marine Drugs

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Chitosan obtained from abundant marine resources has been proven to have a variety of biological activities. However, due to its poor water solubility, chitosan application is limited, and the degradation products of chitosan oligosaccharides are better than chitosan regarding performance. Chitosan oligosaccharides have two kinds of active groups, amino and hydroxyl groups, which can form a variety of derivatives, and the properties of these derivatives can be further improved. In this review, the key structures of chitosan oligosaccharides and recent studies on chitosan oligosaccharide derivatives, including their synthesis methods, are described. Finally, the antimicrobial and antitumor applications of chitosan oligosaccharides and their derivatives are discussed.

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“…With the increasing awareness of safety and environmental protection, bio‐based materials are receiving extensive attention from scientific researchers, providing a wide range of opportunities for interdisciplinary and multidisciplinary research. As an oligomeric polysaccharide, chitosan oligosaccharides (COS) dissolve well under neutral conditions, which greatly increases the scope of application 16,17 . COS is a cationic polysaccharide, which is often used as wall material to embed functional substances such as protein, enzyme, essential oil, and medicine to prepare microcapsules, and it is also used in the preparation of functional textiles 18,19 .…”

Section: Introductionmentioning

confidence: 99%

Preparation of self‐adhesive microcapsules and their application in functional textiles

Tian

Huang

Cheng

et al. 2022

J of Applied Polymer Sci

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This work is devoted to the preparation of self‐adhesive microcapsules and their mechanism of mutual sway with cotton fabrics. Chitosan oligosaccharide (COS) microcapsules were prepared by ionic gelation method and encapsulated with functional substances (lavender oils) to obtain microcapsules with multiple properties (aromatic). The textile auxiliary guar gum (GG) induce the microcapsules to aggregate into a network structure, which increases the chance of microcapsule adhesion on cotton fabrics. Fe3+ further enhance the binding of microcapsules to cotton fabrics through coordination, while ethylenediaminetetraacetic acid (EDTA) can disrupt this binding, thus achieving controlled self‐adhesion. During the five self‐adhesive cycles, the weight gain rate of the microcapsules was 16.00%–17.00% and aromatic content between 0.600–0.700 mg/g when they adhered to the cotton fabric by coordination. After EDTA disrupted the adhesion of the microcapsules, the weight gain rate became 3.00%–3.50% and the content of aromatic was 0.041–0.058 mg/g. Therefore, the microcapsules prepared in this study can achieve multiple recyclable adhesion and de‐adhesion on cotton fabrics by Fe3+ and EDTA, providing new ideas for functionalization and diversification of textiles.

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A dual-prodrug nanoparticle based on chitosan oligosaccharide for enhanced tumor-targeted drug delivery

Cited by 12 publications

References 46 publications

Cell Coding Arrays Based on Fluorescent Glycan Nanoparticles for Cell Line Identification and Cell Contamination Evaluation

Cell Coding Arrays Based on Fluorescent Glycan Nanoparticles for Cell Line Identification and Cell Contamination Evaluation

The Microstructure, Antibacterial and Antitumor Activities of Chitosan Oligosaccharides and Derivatives

Preparation of self‐adhesive microcapsules and their application in functional textiles

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